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See 1 citation in Proc Natl Acad Sci U S A 2013:

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. doi: 10.1073/pnas.1219260110. Epub 2013 Mar 4.

Dimerization of complement factor H-related proteins modulates complement activation in vivo.

Author information

1
Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, London W12 0NN, United Kingdom.

Abstract

The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus. Elucidating the mechanism underlying these associations has been hindered by the lack of understanding of the biological role of CFHR proteins. Here we present unique structural data demonstrating that three of the CFHR proteins contain a shared dimerization motif and that this hitherto unrecognized structural property enables formation of both homodimers and heterodimers. Dimerization confers avidity for tissue-bound complement fragments and enables these proteins to efficiently compete with the physiological complement inhibitor, complement factor H (CFH), for ligand binding. Our data demonstrate that these CFHR proteins function as competitive antagonists of CFH to modulate complement activation in vivo and explain why variation in the CFHRs predisposes to disease.

PMID:
23487775
PMCID:
PMC3606973
DOI:
10.1073/pnas.1219260110
[Indexed for MEDLINE]
Free PMC Article

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