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Pharmacogenomics. 2017 Aug;18(13):1199-1213. doi: 10.2217/pgs-2017-0091. Epub 2017 Jul 26.

Prior opioid exposure influences parents' sharing of their children's CYP2D6 research results.

Author information

1
Division of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
2
College of Medicine, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45267, USA.
3
Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
4
Center for Autoimmune Genomics & Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
5
Division of Genetics & Genomics & The Manton Center for Orphan Disease Research, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
6
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
7
Division of Patient Services, Department of Clinical Shared Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Abstract

AIM:

To determine parents' use of their children's CYP2D6 research result. We hypothesized that perceived utility, likelihood of sharing and actual sharing of results would differ between parents with children previously exposed (cases) or unexposed (controls) to opioids.

METHODS:

We returned results by phone (baseline). We surveyed parents about perceived utility and likelihood of sharing their child's research result at baseline, and actual sharing at 3 and 12 months.

RESULTS:

Cases were more likely than controls to agree that they (p = 0.022) and the doctors (p = 0.041) could use the results to care for their child, to report higher likelihood of sharing (p = 0.042) and to actually share results with the child's doctor (p = 0.026).

CONCLUSION:

Prior opioid exposure influenced perceived clinical utility and sharing behaviors.

KEYWORDS:

CYD2D6; clinic utility; pediatric; pharmacogenetics testing; return of results; sharing of results

PMID:
28745549
PMCID:
PMC5827812
DOI:
10.2217/pgs-2017-0091
[Indexed for MEDLINE]
Free PMC Article

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