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Mycoses. 2016 Dec;59(12):818-821. doi: 10.1111/myc.12540. Epub 2016 Sep 7.

Primary deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man: the first case report and literature review.

Author information

1
Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
2
Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
3
IZZ-Immunologie Zentrum Zürich, Zürich, Switzerland.
4
Section of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
5
School of Medicine, National Yang-Ming University, Taipei, Taiwan.
6
Department of Plastic Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
7
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
8
College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Abstract

Superficial candida infections of the skin are common, but deep cutaneous candidiasis, including secondary dissemination to the skin from systemic candidiasis, candidaemia or primary invasion due to skin defects such as trauma, is rare. These patients are usually immunosuppressed, but immunocompetent hosts can be affected as well. Candida albicans is the most common pathogen. However, non-albicans Candida species can cause deep skin invasion in rare circumstances. We report a case of deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man. Deep tissue invasion was confirmed by skin histopathology examination. The pathogen was initially identified as C. haemulonii using the VITEK® 2 system for microbial identification, but was later determined to be C. duobushaemulonii based on sequencing of the internal transcribed spacer region of ribosomal DNA and D1/D2 region of 26S rDNA. The patient was successfully treated with amphotericin B, followed by fluconazole and surgical intervention. To the best of our knowledge, this is the first case of deep cutaneous infection by C. duobushaemulonii.

KEYWORDS:

Candida duobushaemulonii ; Candida haemulonii complex; candidiasis; cutaneous; deep

PMID:
27600646
DOI:
10.1111/myc.12540
[Indexed for MEDLINE]

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