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PLoS One. 2017 Feb 24;12(2):e0172967. doi: 10.1371/journal.pone.0172967. eCollection 2017.

Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.

Author information

1
Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Institute of Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.
3
Institute for Structural Neurobiology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Abstract

Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.

PMID:
28235022
PMCID:
PMC5325551
DOI:
10.1371/journal.pone.0172967
[Indexed for MEDLINE]
Free PMC Article

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