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Paediatr Perinat Epidemiol. 2018 May;32(3):247-255. doi: 10.1111/ppe.12461. Epub 2018 Mar 23.

Prenatal triptan exposure and neurodevelopmental outcomes in 5-year-old children: Follow-up from the Norwegian Mother and Child Cohort Study.

Author information

1
Pharmacoepidemiology & Drug Safety Research Group, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
2
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
3
Department of Psychology, University of Oslo, Oslo, Norway.
4
Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway.

Abstract

BACKGROUND:

Triptans are commonly used to treat migraine headaches, but data on the long-term safety of these medications during pregnancy are sparse. Triptans have a biologically plausible mechanism for effects on the fetal brain through binding to 5-HT1 -receptors, and previous studies show increased risks of externalising behaviour problems in toddlers exposed to triptans during pregnancy.

METHODS:

We included 3784 children in the Norwegian Mother and Child Cohort Study, whose mothers returned the 5-year-questionnaire and reported a history of migraine or triptan use; 353 (9.3%) mothers reported use of triptans during pregnancy, 1509 (39.9%) reported migraine during pregnancy but no triptan use, and 1922 (50.8%) had migraine prior to pregnancy only. We used linear and log-binomial models with inverse probability weights to examine the association between prenatal triptan exposure and internalising and externalising behaviour, communication, and temperament in 5-year-old children.

RESULTS:

Triptan-exposed children scored higher on the sociability trait than unexposed children of mothers with migraine (β 1.66, 95% confidence interval [0.30, 3.02]). We found no other differences in temperament, or increased risk of behaviour or communication problems.

CONCLUSIONS:

Contrary to results from previous studies in younger children, we found no increased risk of externalising behaviour problems in 5-year-old children exposed to triptans in fetal life. Triptan-exposed children did have slightly more sociable temperaments, but the clinical meaning of this finding is uncertain.

KEYWORDS:

MoBa; behaviour; child; neurodevelopment; pregnancy; triptans

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PMID:
29569251
DOI:
10.1111/ppe.12461

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