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Page 1
PRDM9 and Its Role in Genetic Recombination.
Paigen K, Petkov PM. Paigen K, et al. Trends Genet. 2018 Apr;34(4):291-300. doi: 10.1016/j.tig.2017.12.017. Epub 2018 Jan 21. Trends Genet. 2018. PMID: 29366606 Free PMC article. Review.
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in many species, including humans and mice where PRDM9 has been most intensely studied, …
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it trimethylates histone H3 at lysines 4 and …
PRDM9, a driver of the genetic map.
Grey C, Baudat F, de Massy B. Grey C, et al. PLoS Genet. 2018 Aug 30;14(8):e1007479. doi: 10.1371/journal.pgen.1007479. eCollection 2018 Aug. PLoS Genet. 2018. PMID: 30161134 Free PMC article. Review.
Remarkably, PRDM9 activity leads to the erosion of its own binding sites and the rapid evolution of its DNA-binding domain. PRDM9 may also contribute to reproductive isolation, as it is involved in hybrid sterility potentially due to a reduction of its activity in s …
Remarkably, PRDM9 activity leads to the erosion of its own binding sites and the rapid evolution of its DNA-binding domain. PRDM9 …
PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
Cavassim MIA, Baker Z, Hoge C, Schierup MH, Schumer M, Przeworski M. Cavassim MIA, et al. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2114401119. doi: 10.1073/pnas.2114401119. Proc Natl Acad Sci U S A. 2022. PMID: 35217607 Free PMC article.
Here, we take a phylogenetic approach to identify genes that may be interacting with PRDM9 by leveraging the fact that PRDM9 arose before the origin of vertebrates but was lost many times, either partially or entirely-and with it, its role in recombination. ...We th …
Here, we take a phylogenetic approach to identify genes that may be interacting with PRDM9 by leveraging the fact that PRDM9 a …
PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Imai Y, Biot M, Clément JA, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B. Imai Y, et al. Elife. 2020 Oct 13;9:e57117. doi: 10.7554/eLife.57117. Elife. 2020. PMID: 33047671 Free PMC article.
Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. ...Upon functional analyses during …
Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9 …
PRDM9-directed recombination hotspots depleted near meiotically transcribed genes.
Schwarzkopf EJ, Cornejo OE. Schwarzkopf EJ, et al. Gene. 2022 Mar 1;813:146123. doi: 10.1016/j.gene.2021.146123. Epub 2021 Dec 21. Gene. 2022. PMID: 34952174
PRDM9 drives recombination hotspots in some mammals, including mice and apes. ...We also explored possible DNA sequence motifs associated to clusters of hotspots not tied to transcription or PRDM9. We find evidence of competition between meiotic transcription and re …
PRDM9 drives recombination hotspots in some mammals, including mice and apes. ...We also explored possible DNA sequence motifs associ …
Identification of nonhistone substrates of the lysine methyltransferase PRDM9.
Hanquier JN, Sanders K, Berryhill CA, Sahoo FK, Hudmon A, Vilseck JZ, Cornett EM. Hanquier JN, et al. J Biol Chem. 2023 May;299(5):104651. doi: 10.1016/j.jbc.2023.104651. Epub 2023 Mar 25. J Biol Chem. 2023. PMID: 36972790 Free PMC article.
PRDM9 has been reported to methylate histone H3 at lysine residues 4 and 36; however, PRDM9 KMT activity had not previously been evaluated on nonhistone proteins. Using lysine-oriented peptide libraries to screen potential substrates of PRDM9, we determined t …
PRDM9 has been reported to methylate histone H3 at lysine residues 4 and 36; however, PRDM9 KMT activity had not previously be …
Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility.
Mihola O, Landa V, Pratto F, Brick K, Kobets T, Kusari F, Gasic S, Smagulova F, Grey C, Flachs P, Gergelits V, Tresnak K, Silhavy J, Mlejnek P, Camerini-Otero RD, Pravenec M, Petukhova GV, Trachtulec Z. Mihola O, et al. BMC Biol. 2021 Apr 28;19(1):86. doi: 10.1186/s12915-021-01017-0. BMC Biol. 2021. PMID: 33910563 Free PMC article.
Rat strains carrying the same wild-type Prdm9 allele shared 88% hotspots but strains with different Prdm9 alleles only 3%. After Prdm9 deletion, rat hotspots relocated to functional regions, about 40% to positions corresponding to Prdm9-independent mou …
Rat strains carrying the same wild-type Prdm9 allele shared 88% hotspots but strains with different Prdm9 alleles only 3%. Aft …
PRDM9 forms a trimer by interactions within the zinc finger array.
Schwarz T, Striedner Y, Horner A, Haase K, Kemptner J, Zeppezauer N, Hermann P, Tiemann-Boege I. Schwarz T, et al. Life Sci Alliance. 2019 Jul 15;2(4):e201800291. doi: 10.26508/lsa.201800291. Print 2019 Aug. Life Sci Alliance. 2019. PMID: 31308055 Free PMC article.
It was suggested that PRDM9 is a multimer; however, we do not know the stoichiometry or the components inducing PRDM9 multimerization. ...Based on the migration distance of the PRDM9-DNA complex, we show that PRDM9 forms a trimer. Moreover, this stoich …
It was suggested that PRDM9 is a multimer; however, we do not know the stoichiometry or the components inducing PRDM9 multimer …
Genetics of ovarian insufficiency and defects of folliculogenesis.
França MM, Mendonca BB. França MM, et al. Best Pract Res Clin Endocrinol Metab. 2022 Jan;36(1):101594. doi: 10.1016/j.beem.2021.101594. Epub 2021 Oct 14. Best Pract Res Clin Endocrinol Metab. 2022. PMID: 34794894 Review.
In addition, the majority of genes associated with nonsyndromic POI, widely expanded by high-throughput techniques over the last decade, have been implicated in ovarian development and meiosis/DNA repair pathways (ATG7, ATG9, ANKRD31, BMP8B, BMP15, BMPR1A, BMPR1B, BMPR2, BNC1, BR …
In addition, the majority of genes associated with nonsyndromic POI, widely expanded by high-throughput techniques over the last decade, hav …
Evolution of the recombination regulator PRDM9 in minke whales.
Damm E, Ullrich KK, Amos WB, Odenthal-Hesse L. Damm E, et al. BMC Genomics. 2022 Mar 16;23(1):212. doi: 10.1186/s12864-022-08305-1. BMC Genomics. 2022. PMID: 35296233 Free PMC article.
This study aims to understand the evolution and diversity of Prdm9 in minke whales, which display the most unusual genome reference allele of Prdm9 so far discovered in mammals. ...Common minke whales shared a specific Prdm9 allele across subspecies boundarie …
This study aims to understand the evolution and diversity of Prdm9 in minke whales, which display the most unusual genome reference a …
284 results