Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Expert Opin Drug Deliv. 2016 Dec;13(12):1777-1788. Epub 2016 Jul 6.

Potential of nanoparticles for allergen-specific immunotherapy - use of silica nanoparticles as vaccination platform.

Author information

1
a Department of Molecular Biology, Division of Allergy and Immunology , University of Salzburg , Salzburg , Austria.
2
b Department of Chemistry and Physics of Materials, Materials Chemistry Division , University of Salzburg , Salzburg , Austria.

Abstract

Allergen-specific immunotherapy is the only curative approach for the treatment of allergies. There is an urgent need for improved therapies, which increase both, efficacy and patient compliance. Novel routes of immunization and the use of more advanced vaccine platforms have gained heightened interest in this field. Areas covered: The current status of allergen-specific immunotherapy is summarized and novel routes of immunization and their challenges in the clinics are critically discussed. The use of nanoparticles as novel delivery system for allergy vaccines is comprehensively reviewed. Specifically, the advantages of silica nanoparticles as vaccine carriers and adjuvants are summarized. Expert opinion: Future allergen-specific immunotherapy will combine engineered hypoallergenic vaccines with novel routes of administration, such as the skin. Due to their biodegradability, and the easiness to introduce surface modifications, silica nanoparticles are promising candidates for tailor-made vaccines. By covalently linking allergens and polysaccharides to silica nanoparticles, a versatile vaccination platform can be designed to specifically target antigen-presenting cells, render the formulation hypoallergenic, and introduce immunomodulatory functions. Combining potent skin vaccination methods, such as fractional laser ablation, with nanoparticle-based vaccines addresses all the requirements for safe and efficient therapy of allergic diseases.

KEYWORDS:

Allergy; immunotherapy; nanoparticles; silica; skin vaccination

PMID:
27321476
DOI:
10.1080/17425247.2016.1203898
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center