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Curr Neuropharmacol. 2014 May;12(3):269-72. doi: 10.2174/1570159X11666131204235805.

Potential effects of cannabidiol as a wake-promoting agent.

Author information

1
Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, México;
2
Departamento de Neuropatología Molecular, Instituto de Fisiología Celular Universidad Nacional Autónoma de México, México D.F. México;
3
Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán. México;
4
Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General "Dr. Manuel Gea González", México D.F. México.

Abstract

Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆(9)-tetrahydrocannabinol (∆(9)-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of CBD as a wake-inducing drug.

KEYWORDS:

Dopamine; hypothalamus; marijuana; sleep; sleepiness.

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