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J Diabetes Res. 2016;2016:6321980. doi: 10.1155/2016/6321980. Epub 2015 Dec 10.

Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice.

Author information

1
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
2
Department of Pathology, Rigshospitalet, 2100 Copenhagen, Denmark.
3
Department of Food Science, University of Copenhagen, 1870 Frederiksberg C, Denmark.
4
Bartholin Institute, Rigshospitalet, 2100 Copenhagen, Denmark.

Abstract

Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice. The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions. A distinct bacteria profile rich in staphylococci was found at postnatal days (PND) 1-4 in NOD mice. Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.

PMID:
26783537
PMCID:
PMC4689959
DOI:
10.1155/2016/6321980
[Indexed for MEDLINE]
Free PMC Article

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