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J Atten Disord. 2017 Dec;21(14):1169-1179. doi: 10.1177/1087054714538659. Epub 2014 Jun 26.

Possible Medication-Resistant Deficits in Adult ADHD.

Author information

1
1 Brain Trauma Foundation, New York, NY, USA.
2
2 Stanford University School of Medicine, CA, USA.

Abstract

OBJECTIVE:

The nature of ADHD, especially in adulthood, is not well-understood. Therefore, we explored subcomponents of attention in adult ADHD.

METHOD:

Twenty-three adults with ADHD were tested on neurocognitive and visual tracking performance both while on their regular prescription stimulant medication and while abstaining from the medication for 1 day. Pairwise comparisons to 46 two-for-one matched normal controls were made to detect medication-resistant effects of ADHD, and within-participant comparisons were made to detect medication-sensitive effects in patients.

RESULTS:

Even when on medication, patients performed more poorly than controls on a spatial working memory task, and on visual tracking and simple reaction time tasks immediately following other attention-demanding tasks. Patients' visual tracking performance degraded while off-medication in a manner consistent with reduced vigilance.

CONCLUSION:

There may be persistent cognitive impairments in adult ADHD despite medication. In addition, the benefit of stimulants seems reduced under cognitive fatigue.

KEYWORDS:

assessment; case–control; eye movement; fatigue; ocular pursuit

PMID:
24970719
DOI:
10.1177/1087054714538659
[Indexed for MEDLINE]

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