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Sci Rep. 2018 May 23;8(1):8051. doi: 10.1038/s41598-018-26388-3.

Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques.

Author information

1
Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Rd., Jing'an District, Shanghai, China.
2
Department of Dermatology, Huadong Hospital, Fudan University, 221 West Yan-an Rd., Jing'an District, Shanghai, China.
3
Department of Dermatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Xuhui District, Shanghai, China.
4
Department of Dermatology, Shanghai Dermatology Hospital, 200 Wuyi Road, Chang-ning District, Shanghai, China.
5
Department of Dermatology, Changhai Hospital, The Second Military Medical University, 168 Changhai Rd., Shanghai, China.
6
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, China.
7
Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Rd., Jing'an District, Shanghai, China. luoxiaoqun913@126.com.

Abstract

Psoriasis and parapsoriasis en plaques are chronic inflammatory skin diseases, both representing therapeutic challenge in daily practice and adversely affecting the quality of life. Reactive oxygen species (ROS) has been evidenced to be involved in the pathogenesis of the chronic inflammatory diseases. We now report that hydrogen water, an effective ROS scavenger, has significant and rapid improvement in disease severity and quality of life for patients with psoriasis and parapsoriasis en plaques. At week 8, our parallel-controlled trial revealed 24.4% of patients (10/41) receiving hydrogen-water bathing achieved at least 75% improvement in Psoriasis Area Severity Index (PASI) score compared with 2.9% of patients (1/34) of the control group (Pc = 0.022, OR = 0.094, 95%CI = [0.011, 0.777]). Of patients, 56.1% (23/41) who received bathing achieved at least 50% improvement in PASI score compared with only 17.7%(6/34) of the control group (P = 0.001, OR = 0.168, 95%CI = [0.057, 0.492]). The significant improvement of pruritus was also observed (P = 3.94 × 10-4). Besides, complete response was observed in 33.3% of patients (2/6) of parapsoriasis en plaques and partial response in 66.7% (4/6) at week 8. Our findings suggested that hydrogen-water bathing therapy could fulfill the unmet need for these chronic inflammatory skin diseases.

PMID:
29795283
PMCID:
PMC5966409
DOI:
10.1038/s41598-018-26388-3
[Indexed for MEDLINE]
Free PMC Article

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