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Items: 1 to 20 of 396

1.

Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.

Ernst P, Honegger A, van der Valk F, Ewald C, Mittl PRE, Plückthun A.

Sci Rep. 2019 Nov 7;9(1):16162. doi: 10.1038/s41598-019-52121-9.

2.

New views into class B GPCRs from the crystal structure of PTH1R.

Ehrenmann J, Schöppe J, Klenk C, Plückthun A.

FEBS J. 2019 Oct 31. doi: 10.1111/febs.15115. [Epub ahead of print]

PMID:
31670461
3.

Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins.

Dunne M, Rupf B, Tala M, Qabrati X, Ernst P, Shen Y, Sumrall E, Heeb L, Plückthun A, Loessner MJ, Kilcher S.

Cell Rep. 2019 Oct 29;29(5):1336-1350.e4. doi: 10.1016/j.celrep.2019.09.062.

4.

Structural analysis of biological targets by host:guest crystal lattice engineering.

Ernst P, Plückthun A, Mittl PRE.

Sci Rep. 2019 Oct 23;9(1):15199. doi: 10.1038/s41598-019-51017-y.

5.

Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome.

Renko M, Fiedler M, Rutherford TJ, Schaefer JV, Plückthun A, Bienz M.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20977-20983. doi: 10.1073/pnas.1912705116. Epub 2019 Sep 30.

6.

Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors.

Balakrishnan A, Rajan A, Salter AI, Kosasih PL, Wu Q, Voutsinas J, Jensen MC, Plückthun A, Riddell SR.

Clin Cancer Res. 2019 Sep 23. doi: 10.1158/1078-0432.CCR-19-1479. [Epub ahead of print]

PMID:
31548346
7.

Facile Site-Specific Multiconjugation Strategies in Recombinant Proteins Produced in Bacteria.

Merten H, Schaefer JV, Brandl F, Zangemeister-Wittke U, Plückthun A.

Methods Mol Biol. 2019;2033:253-273. doi: 10.1007/978-1-4939-9654-4_17.

PMID:
31332759
8.

Site-Selective Enzymatic Labeling of Designed Ankyrin Repeat Proteins Using Protein Farnesyltransferase.

Zhang Y, Auger S, Schaefer JV, Plückthun A, Distefano MD.

Methods Mol Biol. 2019;2033:207-219. doi: 10.1007/978-1-4939-9654-4_14.

PMID:
31332756
9.

Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins.

Brandl F, Merten H, Zimmermann M, Béhé M, Zangemeister-Wittke U, Plückthun A.

J Control Release. 2019 Aug 10;307:379-392. doi: 10.1016/j.jconrel.2019.06.030. Epub 2019 Jun 25.

PMID:
31252038
10.

Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing.

Lorenzer C, Streußnig S, Tot E, Winkler AM, Merten H, Brandl F, Sayers EJ, Watson P, Jones AT, Zangemeister-Wittke U, Plückthun A, Winkler J.

Eur J Pharm Biopharm. 2019 Aug;141:37-50. doi: 10.1016/j.ejpb.2019.05.015. Epub 2019 May 16.

PMID:
31103742
11.

Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets.

Radom F, Paci E, Plückthun A.

J Mol Biol. 2019 Jul 12;431(15):2852-2868. doi: 10.1016/j.jmb.2019.05.005. Epub 2019 May 11.

PMID:
31082438
12.

High-Throughput Quantification of Surface Protein Internalization and Degradation.

Stüber JC, Kast F, Plückthun A.

ACS Chem Biol. 2019 Jun 21;14(6):1154-1163. doi: 10.1021/acschembio.9b00016. Epub 2019 May 14.

PMID:
31050891
13.

Insight into microtubule nucleation from tubulin-capping proteins.

Campanacci V, Urvoas A, Cantos-Fernandes S, Aumont-Nicaise M, Arteni AA, Velours C, Valerio-Lepiniec M, Dreier B, Plückthun A, Pilon A, Poüs C, Minard P, Gigant B.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):9859-9864. doi: 10.1073/pnas.1813559116. Epub 2019 Apr 29.

14.

A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins.

Meksiriporn B, Ludwicki MB, Stephens EA, Jiang A, Lee HC, Waraho-Zhmayev D, Kummer L, Brandl F, Plückthun A, DeLisa MP.

Nat Commun. 2019 Apr 23;10(1):1830. doi: 10.1038/s41467-019-09854-y.

15.

Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.

Andres F, Iamele L, Meyer T, Stüber JC, Kast F, Gherardi E, Niemann HH, Plückthun A.

J Mol Biol. 2019 May 3;431(10):2020-2039. doi: 10.1016/j.jmb.2019.03.024. Epub 2019 Mar 28.

PMID:
30930049
16.

High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor.

Heine P, Witt G, Gilardi A, Gribbon P, Kummer L, Plückthun A.

SLAS Discov. 2019 Oct;24(9):915-927. doi: 10.1177/2472555219837344. Epub 2019 Mar 29.

PMID:
30925845
17.

Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization.

Deprey K, Becker L, Kritzer J, Plückthun A.

Bioconjug Chem. 2019 Apr 17;30(4):1006-1027. doi: 10.1021/acs.bioconjchem.9b00112. Epub 2019 Apr 5.

PMID:
30882208
18.

Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli.

Tomatis PE, Schütz M, Umudumov E, Plückthun A.

Sci Rep. 2019 Feb 21;9(1):2483. doi: 10.1038/s41598-019-39492-9.

19.

Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer.

Schwill M, Tamaskovic R, Gajadhar AS, Kast F, White FM, Plückthun A.

Sci Signal. 2019 Jan 22;12(565). pii: eaau2875. doi: 10.1126/scisignal.aau2875.

20.

In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex.

Kumar A, Plückthun A.

PLoS One. 2019 Jan 8;14(1):e0210131. doi: 10.1371/journal.pone.0210131. eCollection 2019.

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