Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation

Ann N Y Acad Sci. 1999:886:265-8. doi: 10.1111/j.1749-6632.1999.tb09432.x.
No abstract available

Publication types

  • Review

MeSH terms

  • Alkyl and Aryl Transferases / antagonists & inhibitors*
  • Animals
  • Antineoplastic Agents / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Farnesyltranstransferase
  • Genes, erbB-2*
  • Mammary Neoplasms, Experimental / enzymology
  • Mammary Neoplasms, Experimental / genetics
  • Mammary Neoplasms, Experimental / pathology*
  • Mice
  • Mice, Transgenic
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors*
  • Mitogen-Activated Protein Kinases / metabolism
  • Phosphorylation
  • Ribosomal Protein S6 Kinases / antagonists & inhibitors*
  • Ribosomal Protein S6 Kinases / metabolism
  • Transforming Growth Factors / genetics*

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Transforming Growth Factors
  • Alkyl and Aryl Transferases
  • Farnesyltranstransferase
  • Ribosomal Protein S6 Kinases
  • Mitogen-Activated Protein Kinases