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Page 1
Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis.
Polonikov AV, Ushachev DV, Ivanov VP, Churnosov MI, Freidin MB, Ataman AV, Harbuzova VY, Bykanova MA, Bushueva OY, Solodilova MA. Polonikov AV, et al. J Hypertens. 2015 Nov;33(11):2265-77. doi: 10.1097/HJH.0000000000000699. J Hypertens. 2015. PMID: 26335431
OBJECTIVE: The study was designed to assess the effects of polymorphisms in genes associated with essential hypertension on the variation of erythrocyte membrane proteins (EMPs) in hypertensive patients. METHODS: Major EMPs content was analyzed in blood from 1162 un …
OBJECTIVE: The study was designed to assess the effects of polymorphisms in genes associated with essential hypertension on th …
Unknown face of known drugs - what else can we expect from angiotensin converting enzyme inhibitors?
Wzgarda A, Kleszcz R, Prokop M, Regulska K, Regulski M, Paluszczak J, Stanisz BJ. Wzgarda A, et al. Eur J Pharmacol. 2017 Feb 15;797:9-19. doi: 10.1016/j.ejphar.2016.12.031. Epub 2017 Jan 10. Eur J Pharmacol. 2017. PMID: 28087255 Review.
Moreover, there are more and more reports showing evidence that ACEI can be beneficial in the treatment of many other diseases and the pleiotropic activity of ACEI is mainly based on their antioxidant properties. In this paper we focus on the less obvious possibilities of …
Moreover, there are more and more reports showing evidence that ACEI can be beneficial in the treatment of many other diseases and the pl …
Pleiotropic effect of common variants at ABO Glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme.
Yamagata University Genomic Cohort Consortium (YUGCC). Yamagata University Genomic Cohort Consortium (YUGCC). PLoS One. 2014 Feb 28;9(2):e55903. doi: 10.1371/journal.pone.0055903. eCollection 2014. PLoS One. 2014. PMID: 24586218 Free PMC article.
In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase locus in 9q32 with the plasma levels of pancreatic lipase (P-LIP), in addition to successful confirmation of the known ABO association of an …
In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase …
Specific and common genes implicated across major mental disorders: a review of meta-analysis studies.
Gatt JM, Burton KL, Williams LM, Schofield PR. Gatt JM, et al. J Psychiatr Res. 2015 Jan;60:1-13. doi: 10.1016/j.jpsychires.2014.09.014. Epub 2014 Sep 28. J Psychiatr Res. 2015. PMID: 25287955 Review.
A total of 134 genes (206 variants) were identified as significantly associated risk variants for MDD, AD, ADHD, SZ or BD. Null genetic effects were also reported for 195 genes (426 variants). 13 genetic variants were shared in common between two or more diso …
A total of 134 genes (206 variants) were identified as significantly associated risk variants for MDD, AD, ADHD, SZ or BD. Null genetic …
Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity.
Nacmias B, Bagnoli S, Tedde A, Cellini E, Bessi V, Guarnieri B, Ortensi L, Piacentini S, Bracco L, Sorbi S. Nacmias B, et al. Arch Gerontol Geriatr. 2007 Sep-Oct;45(2):201-6. doi: 10.1016/j.archger.2006.10.011. Epub 2006 Dec 19. Arch Gerontol Geriatr. 2007. PMID: 17182125
A recent, large meta-analysis has reproposed the role of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism as a risk factor for Alzheimer's disease (AD). ...Centenarians show the highest allele D frequency, although the value is not signi …
A recent, large meta-analysis has reproposed the role of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorp …
Genetic associations with human longevity at the APOE and ACE loci.
Schächter F, Faure-Delanef L, Guénot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D. Schächter F, et al. Nat Genet. 1994 Jan;6(1):29-32. doi: 10.1038/ng0194-29. Nat Genet. 1994. PMID: 8136829
In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. ...These associations provide examples of genetic …
In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians ( …
Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study.
Rahmutula D, Nakayama T, Izumi Y, Ozawa Y, Shimabukuro H, Kawamura H, Zhen-Wang S, Xiong-Wang J, Aisa M, Run-Yang C, Mahmut M, Mahsut R, Hen-Chen Z. Rahmutula D, et al. J Gerontol A Biol Sci Med Sci. 2002 Jan;57(1):M57-60. doi: 10.1093/gerona/57.1.m57. J Gerontol A Biol Sci Med Sci. 2002. PMID: 11773214
METHODS: We performed a correlation study between the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene and longevity by comparing distributions of the polymorphism between three different ethnic groups in this region. ...W …
METHODS: We performed a correlation study between the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme ( …
Genetic contribution to aging: deleterious and helpful genes define life expectancy.
Lao JI, Montoriol C, Morer I, Beyer K. Lao JI, et al. Ann N Y Acad Sci. 2005 Dec;1057:50-63. doi: 10.1196/annals.1356.003. Ann N Y Acad Sci. 2005. PMID: 16399887
For the best understanding of aging, we must consider a genetic pool in which genes with negative effects (deleterious genes that shorten the life span) interact with genes with positive effects (helpful genes that promote longevity) in a constant epistatic r …
For the best understanding of aging, we must consider a genetic pool in which genes with negative effects (deleterious genes t …
Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma, and APOE) on human fertility.
Corbo RM, Ulizzi L, Piombo L, Scacchi R. Corbo RM, et al. Biogerontology. 2008 Oct;9(5):317-23. doi: 10.1007/s10522-008-9143-9. Epub 2008 Apr 26. Biogerontology. 2008. PMID: 18443916
The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-gamma, APOE) in order to determine whether they have a pleiotropic action at different life ages. ...The logistic regression analysis indicate …
The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-gamma, AP …