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Science. 2016 Sep 16;353(6305):1237-40. doi: 10.1126/science.aaf6638.

Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment.

Author information

1
Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. george.lomonossoff@jic.ac.uk.
2
Medicago, 1020 Route de l'Église, Bureau 600, Quebec City, Quebec G1V 3V9, Canada.

Abstract

The ability to express heterologous proteins in plants has led to the concept of using plants as "bioreactors" or "biofactories" for the production of pharmaceutical proteins. Although initial studies were promising, the pathway to commercialization and deployment in a clinical setting has proven to be a somewhat rocky road. This Review examines the technical developments that have led to the current increase in interest in the use of plants for the production of pharmaceutical proteins, particularly in the context of clinical trials.

PMID:
27634524
DOI:
10.1126/science.aaf6638
[Indexed for MEDLINE]

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