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J Cosmet Laser Ther. 2005 Dec;7(3-4):159-62.

Pilot study to determine the efficacy of ALA-PDT photo-rejuvenation for the treatment of facial ageing.

Author information

1
Cranley Clinic, London, UK. cranleyuk@aol.com

Abstract

OBJECTIVE:

The study was divided into two parts. The objective of the preliminary study was to evaluate the optimum dose and tolerance of 5-aminolaevulinic acid (5-ALA) compared to a placebo cream with a 633-nm LED light in normal, healthy, volunteer forearm skin. The second study was to establish if ALA-PDT treatments improve the signs of ageing.

RESULTS:

Threshold photosensitization was observed using 5% 5-ALA under plastic occlusion for 30 minutes following a dose response study of forearm skin. Mild improvement was observed, using this concentration and time, for periorbital skin aging. Other anecdotal positive results of photo-rejuvenation are reported for facial and chest areas.

PMID:
16414903
DOI:
10.1080/14764170500344179
[Indexed for MEDLINE]

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