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Items: 1 to 20 of 96

1.

Hachimoji DNA and RNA: A genetic system with eight building blocks.

Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE Jr, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J Jr, Georgiadis MM, Benner SA.

Science. 2019 Feb 22;363(6429):884-887. doi: 10.1126/science.aat0971.

PMID:
30792304
2.

Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif.

Shelke SA, Shao Y, Laski A, Koirala D, Weissman BP, Fuller JR, Tan X, Constantin TP, Waggoner AS, Bruchez MP, Armitage BA, Piccirilli JA.

Nat Commun. 2018 Oct 31;9(1):4542. doi: 10.1038/s41467-018-06942-3.

3.

Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.

Lu J, Koo SC, Weissman BP, Harris ME, Li NS, Piccirilli JA.

Biochemistry. 2018 Jun 26;57(25):3465-3472. doi: 10.1021/acs.biochem.8b00031. Epub 2018 May 17.

PMID:
29733591
4.

Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.

Koirala D, Shelke SA, Dupont M, Ruiz S, DasGupta S, Bailey LJ, Benner SA, Piccirilli JA.

Nucleic Acids Res. 2018 Mar 16;46(5):2624-2635. doi: 10.1093/nar/gkx1292.

5.

Synthesis of 5'-Thio-3'-O-ribonucleoside Phosphoramidites.

Li NS, Lu J, Piccirilli JA.

J Org Chem. 2017 Dec 1;82(23):12003-12013. doi: 10.1021/acs.joc.7b01484. Epub 2017 Oct 31.

PMID:
29049877
6.

Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.

Harris ME, York DM, Piccirilli JA, Anderson VE.

Methods Enzymol. 2017;596:433-457. doi: 10.1016/bs.mie.2017.07.017. Epub 2017 Sep 5.

PMID:
28911780
7.

Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.

DasGupta S, Suslov NB, Piccirilli JA.

J Am Chem Soc. 2017 Jul 19;139(28):9591-9597. doi: 10.1021/jacs.7b03655. Epub 2017 Jul 3.

8.

Synthesizing topological structures containing RNA.

Liu D, Shao Y, Chen G, Tse-Dinh YC, Piccirilli JA, Weizmann Y.

Nat Commun. 2017 Mar 31;8:14936. doi: 10.1038/ncomms14936.

9.

Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.

Sundaram KM, Zhang Y, Mitra AK, Kouadio JK, Gwin K, Kossiakoff AA, Roman BB, Lengyel E, Piccirilli JA.

Cancer Res. 2017 Apr 1;77(7):1684-1696. doi: 10.1158/0008-5472.CAN-16-1454. Epub 2017 Feb 15.

10.

RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.

Miao Z, Adamiak RW, Antczak M, Batey RT, Becka AJ, Biesiada M, Boniecki MJ, Bujnicki JM, Chen SJ, Cheng CY, Chou FC, Ferré-D'Amaré AR, Das R, Dawson WK, Ding F, Dokholyan NV, Dunin-Horkawicz S, Geniesse C, Kappel K, Kladwang W, Krokhotin A, Łach GE, Major F, Mann TH, Magnus M, Pachulska-Wieczorek K, Patel DJ, Piccirilli JA, Popenda M, Purzycka KJ, Ren A, Rice GM, Santalucia J Jr, Sarzynska J, Szachniuk M, Tandon A, Trausch JJ, Tian S, Wang J, Weeks KM, Williams B 2nd, Xiao Y, Xu X, Zhang D, Zok T, Westhof E.

RNA. 2017 May;23(5):655-672. doi: 10.1261/rna.060368.116. Epub 2017 Jan 30.

11.

Drug conjugated nanoparticles activated by cancer cell specific mRNA.

Gossai NP, Naumann JA, Li NS, Zamora EA, Gordon DJ, Piccirilli JA, Gordon PM.

Oncotarget. 2016 Jun 21;7(25):38243-38256. doi: 10.18632/oncotarget.9430.

12.

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.

Biondi E, Lane JD, Das D, Dasgupta S, Piccirilli JA, Hoshika S, Bradley KM, Krantz BA, Benner SA.

Nucleic Acids Res. 2016 Nov 16;44(20):9565-9577. Epub 2016 Oct 3.

13.

Efficient Synthetic Approach to Linear Dasatinib-DNA Conjugates by Click Chemistry.

Li NS, Gossai NP, Naumann JA, Gordon PM, Piccirilli JA.

Bioconjug Chem. 2016 Oct 19;27(10):2575-2579. doi: 10.1021/acs.bioconjchem.6b00557. Epub 2016 Oct 6.

PMID:
27690393
14.

Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.

Shao Y, Huang H, Qin D, Li NS, Koide A, Staley JP, Koide S, Kossiakoff AA, Piccirilli JA.

J Mol Biol. 2016 Oct 9;428(20):4100-4114. doi: 10.1016/j.jmb.2016.08.029. Epub 2016 Sep 2.

15.

Reverse transcriptases lend a hand in splicing catalysis.

Piccirilli JA, Staley JP.

Nat Struct Mol Biol. 2016 Jun 7;23(6):507-9. doi: 10.1038/nsmb.3242. No abstract available.

PMID:
27273636
16.

Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+).

Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris ME.

Chem Commun (Camb). 2016 Mar 25;52(24):4462-5. doi: 10.1039/c5cc10212j.

17.

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.

Roy S, Ly D, Castro CD, Li NS, Hawk AJ, Altman JD, Meredith SC, Piccirilli JA, Moody DB, Adams EJ.

J Immunol. 2016 Feb 15;196(4):1933-42. doi: 10.4049/jimmunol.1502202. Epub 2016 Jan 11.

18.

An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.

Sengupta RN, Van Schie SN, Giambaşu G, Dai Q, Yesselman JD, York D, Piccirilli JA, Herschlag D.

RNA. 2016 Jan;22(1):32-48. doi: 10.1261/rna.053710.115. Epub 2015 Nov 13.

19.

Crystal structure of the Varkud satellite ribozyme.

Suslov NB, DasGupta S, Huang H, Fuller JR, Lilley DM, Rice PA, Piccirilli JA.

Nat Chem Biol. 2015 Nov;11(11):840-6. doi: 10.1038/nchembio.1929. Epub 2015 Sep 28.

20.

A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.

Hernandez AR, Shao Y, Hoshika S, Yang Z, Shelke SA, Herrou J, Kim HJ, Kim MJ, Piccirilli JA, Benner SA.

Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9853-6. doi: 10.1002/anie.201504731. Epub 2015 Jul 16.

PMID:
26223188

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