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PLoS One. 2014 Feb 4;9(2):e88083. doi: 10.1371/journal.pone.0088083. eCollection 2014.

Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses.

Author information

1
Robert Koch Institute, Wernigerode, Germany.
2
Institute of Microbiology and Epizootics, Free University Berlin, Berlin, Germany.
3
Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
4
National Food Institute, Technical University of Denmark, Lyngby, Denmark.
5
The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
6
Department of Epidemiology, College of Public Health, the University of Iowa, Iowa City, Iowa, United States of America.
7
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
8
Istituto Superiore di Sanità, Rome, Italy.
9
Centre National de Référence Staphylococcus aureus, Microbiology Department, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
10
European Centre for Disease Prevention and Control, Stockholm, Sweden.
11
Department of Microbiology, Scottish MRSA Reference Laboratory (SMRSARL), Glasgow Royal Infirmary, Glasgow, United Kingdom.
12
Labor Dr. Böse GmbH, Harsum, Germany.

Abstract

In the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the population structure of CC398 through mutation discovery at 97 genetic housekeeping loci, which are distributed along the CC398 chromosome within 195 CC398 isolates, collected from various countries and host species, including humans. Most of the isolates in this collection were received from collaborating microbiologists, who had preserved them over years. We discovered 96 bi-allelic polymorphisms, and phylogenetic analyses revealed that an epidemic sub-clone within CC398 (dubbed 'clade (C)') has spread within and between equine hospitals, where it causes nosocomial infections in horses and colonises the personnel. While clade (C) was strongly associated with S. aureus from horses in veterinary-care settings (p = 2 × 10(-7)), it remained extremely rare among S. aureus isolates from human infections.

PMID:
24505386
PMCID:
PMC3913741
DOI:
10.1371/journal.pone.0088083
[Indexed for MEDLINE]
Free PMC Article

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