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Mol Carcinog. 2015 Jul;54(7):523-31. doi: 10.1002/mc.22117. Epub 2013 Nov 30.
Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder.
Junqueira-Neto S1,
Vieira FQ1,2,
Montezuma D1,3,
Costa NR1,
Antunes L4,
Baptista T1,
Oliveira AI1,
Graça I1,2,
Rodrigues Â3,
Magalhães JS5,
Oliveira J5,
Henrique R1,3,6,
Jerónimo C1,6.
- 1
- Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
- 2
- School of Allied Health Sciences ESTSP, Polytechnic of Porto, Porto, Portugal.
- 3
- Department of Pathology, Portuguese Oncology Institute, Porto, Portugal.
- 4
- Department of Epidemiology, Portuguese Oncology Institute, Porto, Portugal.
- 5
- Department of Urology, Portuguese Oncology Institute, Porto, Portugal.
- 6
- Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.
Abstract
Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
© 2013 Wiley Periodicals, Inc.
KEYWORDS:
apoptosis; bladder cancer; class I HDACs; viability
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