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J Clin Virol. 2015 Aug;69:48-51. doi: 10.1016/j.jcv.2015.05.019. Epub 2015 May 29.

Persistent viremia and urine shedding of tick-borne encephalitis virus in an infected immunosuppressed patient from a new epidemic cluster in North-Eastern Italy.

Author information

1
Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.
2
Infectious Diseases Clinic, Santa Maria Misericordia University Hospital, Udine, Italy.
3
Hematology Unit, Department of Oncology, University Hospital, Trieste, Italy.
4
Infectious Diseases Unit, University Hospital, Trieste, Italy.
5
Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
6
Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
7
Department of Medical, Surgical and Health Sciences, University of Trieste, Italy; Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy. Electronic address: pdagaro@units.it.

Abstract

A persistent tick-borne encephalitis virus infection in an immune-suppressed patient is presented. Such an unusual clinical case offers the unique chance of detecting persistent viremia associated to the erythrocyte fraction and shedding of the virus in the urine for more than six weeks. The infection occurred in a new area of the Friuli Venezia-Giulia region (North Eastern Italy) where two additional cases are also being reported.

KEYWORDS:

Friuli-Venezia Giulia region; Immuno-compromized host; Italy; Persistent infection; Real-time PCR; Sequencing; TBEV; Tick-borne encephalitis; Trieste; Virus isolation

PMID:
26209378
DOI:
10.1016/j.jcv.2015.05.019
[Indexed for MEDLINE]

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