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Items: 1 to 20 of 445

1.

Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells.

Viswanatha R, Li Z, Hu Y, Perrimon N.

Elife. 2018 Jul 27;7. pii: e36333. doi: 10.7554/eLife.36333.

2.

ovoD Co-selection: A Method for Enriching CRISPR/Cas9-Edited Alleles in Drosophila.

Ewen-Campen B, Perrimon N.

G3 (Bethesda). 2018 Jul 31;8(8):2749-2756. doi: 10.1534/g3.118.200498.

3.

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.

Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL.

J Clin Invest. 2018 Jul 2;128(7):3008-3023. doi: 10.1172/JCI95231. Epub 2018 Jun 11.

4.

Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM.

Jia Y, Xu RG, Ren X, Ewen-Campen B, Rajakumar R, Zirin J, Yang-Zhou D, Zhu R, Wang F, Mao D, Peng P, Qiao HH, Wang X, Liu LP, Xu B, Ji JY, Liu Q, Sun J, Perrimon N, Ni JQ.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4719-4724. doi: 10.1073/pnas.1800677115. Epub 2018 Apr 16.

PMID:
29666231
5.

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.

Hong S, Song W, Zushin PH, Liu B, Jedrychowski MP, Mina AI, Deng Z, Cabarkapa D, Hall JA, Palmer CJ, Aliakbarian H, Szpyt J, Gygi SP, Tavakkoli A, Lynch L, Perrimon N, Banks AS.

Mol Metab. 2018 Jun;12:25-38. doi: 10.1016/j.molmet.2018.03.012. Epub 2018 Mar 29.

6.

The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.

Tang HW, Hu Y, Chen CL, Xia B, Zirin J, Yuan M, Asara JM, Rabinow L, Perrimon N.

Cell Metab. 2018 May 1;27(5):1040-1054.e8. doi: 10.1016/j.cmet.2018.02.023. Epub 2018 Mar 29.

PMID:
29606597
7.

Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.

Zhang T, Song W, Li Z, Qian W, Wei L, Yang Y, Wang W, Zhou X, Meng M, Peng J, Xia Q, Perrimon N, Cheng D.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3960-3965. doi: 10.1073/pnas.1800435115. Epub 2018 Mar 22.

PMID:
29567866
8.

A gene-specific T2A-GAL4 library for Drosophila.

Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ.

Elife. 2018 Mar 22;7. pii: e35574. doi: 10.7554/eLife.35574.

9.

Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex.

Guo J, Tang HW, Li J, Perrimon N, Yan D.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3674-3679. doi: 10.1073/pnas.1720945115. Epub 2018 Mar 19.

PMID:
29555755
10.

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.

He L, Si G, Huang J, Samuel ADT, Perrimon N.

Nature. 2018 Mar 1;555(7694):103-106. doi: 10.1038/nature25744. Epub 2018 Feb 7.

PMID:
29414942
11.

Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells.

Mohr SE, Rudd K, Hu Y, Song WR, Gilly Q, Buckner M, Housden BE, Kelley C, Zirin J, Tao R, Amador G, Sierzputowska K, Comjean A, Perrimon N.

G3 (Bethesda). 2018 Feb 2;8(2):631-641. doi: 10.1534/g3.117.300447.

12.

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Housden BE, Li Z, Kelley C, Wang Y, Hu Y, Valvezan AJ, Manning BD, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10755-E10762. doi: 10.1073/pnas.1713362114. Epub 2017 Nov 28.

13.

Molecular Interaction Search Tool (MIST): an integrated resource for mining gene and protein interaction data.

Hu Y, Vinayagam A, Nand A, Comjean A, Chung V, Hao T, Mohr SE, Perrimon N.

Nucleic Acids Res. 2018 Jan 4;46(D1):D567-D574. doi: 10.1093/nar/gkx1116.

14.

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD.

Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19.

PMID:
29056426
15.

A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.

Rajan A, Housden BE, Wirtz-Peitz F, Holderbaum L, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):83-98.e6. doi: 10.1016/j.devcel.2017.09.007.

PMID:
29017032
16.

Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR.

Ewen-Campen B, Mohr SE, Hu Y, Perrimon N.

Dev Cell. 2017 Oct 9;43(1):6-9. doi: 10.1016/j.devcel.2017.09.020. Review.

PMID:
29017030
17.

Optimized strategy for in vivo Cas9-activation in Drosophila.

Ewen-Campen B, Yang-Zhou D, Fernandes VR, González DP, Liu LP, Tao R, Ren X, Sun J, Hu Y, Zirin J, Mohr SE, Ni JQ, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9409-9414. doi: 10.1073/pnas.1707635114. Epub 2017 Aug 14.

18.

Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model.

Song W, Owusu-Ansah E, Hu Y, Cheng D, Ni X, Zirin J, Perrimon N.

Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708037. doi: 10.1073/pnas.1708037114. [Epub ahead of print]

19.

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.

Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW.

Cell Rep. 2017 Jul 18;20(3):721-736. doi: 10.1016/j.celrep.2017.06.074.

20.

Gene2Function: An Integrated Online Resource for Gene Function Discovery.

Hu Y, Comjean A, Mohr SE; FlyBase Consortium, Perrimon N.

G3 (Bethesda). 2017 Aug 7;7(8):2855-2858. doi: 10.1534/g3.117.043885.

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