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Items: 1 to 20 of 50

1.

Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel.

Li J, Ostmeyer J, Cuello LG, Perozo E, Roux B.

J Gen Physiol. 2018 Aug 2. pii: jgp.201812082. doi: 10.1085/jgp.201812082. [Epub ahead of print]

PMID:
30072373
2.

Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.

Lau C, Hunter MJ, Stewart A, Perozo E, Vandenberg JI.

J Physiol. 2018 Apr 1;596(7):1107-1119. doi: 10.1113/JP274888. Epub 2018 Mar 5.

PMID:
29377132
3.

Structural Dynamics of the MscL C-terminal Domain.

Bavi N, Martinac AD, Cortes DM, Bavi O, Ridone P, Nomura T, Hill AP, Martinac B, Perozo E.

Sci Rep. 2017 Dec 8;7(1):17229. doi: 10.1038/s41598-017-17396-w.

4.

The gating cycle of a K+ channel at atomic resolution.

Cuello LG, Cortes DM, Perozo E.

Elife. 2017 Nov 22;6. pii: e28032. doi: 10.7554/eLife.28032.

5.

Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation.

Li J, Ostmeyer J, Boulanger E, Rui H, Perozo E, Roux B.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11145-11150. doi: 10.1073/pnas.1706983114. Epub 2017 Oct 2.

6.

Towards a Structural View of Drug Binding to hERG K+ Channels.

Vandenberg JI, Perozo E, Allen TW.

Trends Pharmacol Sci. 2017 Oct;38(10):899-907. doi: 10.1016/j.tips.2017.06.004. Epub 2017 Jul 12. Review.

PMID:
28711156
7.

Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy.

Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT.

J Am Chem Soc. 2017 Jul 5;139(26):8837-8845. doi: 10.1021/jacs.7b01594. Epub 2017 May 12.

8.

Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy.

Kratochvil HT, Carr JK, Matulef K, Annen AW, Li H, Maj M, Ostmeyer J, Serrano AL, Raghuraman H, Moran SD, Skinner JL, Perozo E, Roux B, Valiyaveetil FI, Zanni MT.

Science. 2016 Sep 2;353(6303):1040-1044.

9.

From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins.

Laguerre A, Löhr F, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM, Bernhard F, Dötsch V.

Structure. 2016 Oct 4;24(10):1830-1841. doi: 10.1016/j.str.2016.07.017. Epub 2016 Sep 15.

10.

Toward a structural blueprint for bilayer-mediated channel mechanosensitivity.

Bavi N, Cox CD, Perozo E, Martinac B.

Channels (Austin). 2017 Mar 4;11(2):91-93. doi: 10.1080/19336950.2016.1224624. Epub 2016 Aug 17. No abstract available.

11.

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.

Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B.

Nat Commun. 2016 Jun 22;7:11984. doi: 10.1038/ncomms11984.

12.

Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channel.

Medovoy D, Perozo E, Roux B.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1722-32. doi: 10.1016/j.bbamem.2016.02.019. Epub 2016 Feb 16.

13.

Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.

Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, Reddy BG, Islam S, Bartesaghi A, Perozo E, Subramaniam S.

Cell. 2016 Feb 11;164(4):747-56. doi: 10.1016/j.cell.2015.12.055.

14.

Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.

Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA.

Structure. 2016 Feb 2;24(2):300-9. doi: 10.1016/j.str.2015.11.014. Epub 2015 Dec 31.

15.

Resting state of the human proton channel dimer in a lipid bilayer.

Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5926-35. doi: 10.1073/pnas.1515043112. Epub 2015 Oct 6.

16.

Biomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling.

van der Cruijsen EA, Koers EJ, Sauvée C, Hulse RE, Weingarth M, Ouari O, Perozo E, Tordo P, Baldus M.

Chemistry. 2015 Sep 7;21(37):12971-7. doi: 10.1002/chem.201501376.

PMID:
26315337
17.

xMDFF: molecular dynamics flexible fitting of low-resolution X-ray structures.

McGreevy R, Singharoy A, Li Q, Zhang J, Xu D, Perozo E, Schulten K.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2344-55. doi: 10.1107/S1399004714013856. Epub 2014 Aug 29.

18.

Molecular mechanism of Mg2+-dependent gating in CorA.

Dalmas O, Sompornpisut P, Bezanilla F, Perozo E.

Nat Commun. 2014 Apr 2;5:3590. doi: 10.1038/ncomms4590.

19.

Conformational dynamics at the inner gate of KcsA during activation.

Hulse RE, Sachleben JR, Wen PC, Moradi M, Tajkhorshid E, Perozo E.

Biochemistry. 2014 Apr 29;53(16):2557-9. doi: 10.1021/bi500168u. Epub 2014 Apr 18.

20.

A repulsion mechanism explains magnesium permeation and selectivity in CorA.

Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3002-7. doi: 10.1073/pnas.1319054111. Epub 2014 Feb 10.

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