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Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.

Laghezza A, Piemontese L, Cerchia C, Montanari R, Capelli D, Giudici M, Crestani M, Tortorella P, Peiretti F, Pochetti G, Lavecchia A, Loiodice F.

J Med Chem. 2018 Sep 27;61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. Epub 2018 Sep 18.


The beta secretase BACE1 regulates the expression of insulin receptor in the liver.

Meakin PJ, Mezzapesa A, Benabou E, Haas ME, Bonardo B, Grino M, Brunel JM, Desbois-Mouthon C, Biddinger SB, Govers R, Ashford MLJ, Peiretti F.

Nat Commun. 2018 Apr 3;9(1):1306. doi: 10.1038/s41467-018-03755-2.


Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity.

Blanchet M, Borselli D, Rodallec A, Peiretti F, Vidal N, Bolla JM, Digiorgio C, Morrison KR, Wuest WM, Brunel JM.

ChemMedChem. 2018 May 23;13(10):1018-1027. doi: 10.1002/cmdc.201800073. Epub 2018 Apr 10.


Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.

Brusotti G, Montanari R, Capelli D, Cattaneo G, Laghezza A, Tortorella P, Loiodice F, Peiretti F, Bonardo B, Paiardini A, Calleri E, Pochetti G.

Sci Rep. 2017 Jul 18;7(1):5777. doi: 10.1038/s41598-017-05666-6.


Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid.

Maleeva G, Peiretti F, Zhorov BS, Bregestovski P.

Front Mol Neurosci. 2017 May 16;10:125. doi: 10.3389/fnmol.2017.00125. eCollection 2017.


Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

Saultier P, Vidal L, Canault M, Bernot D, Falaise C, Pouymayou C, Bordet JC, Saut N, Rostan A, Baccini V, Peiretti F, Favier M, Lucca P, Deleuze JF, Olaso R, Boland A, Morange PE, Gachet C, Malergue F, Fauré S, Eckly A, Trégouët DA, Poggi M, Alessi MC.

Haematologica. 2017 Jun;102(6):1006-1016. doi: 10.3324/haematol.2016.153577. Epub 2017 Mar 2.


Ascorbic acid drives the differentiation of mesoderm-derived embryonic stem cells. Involvement of p38 MAPK/CREB and SVCT2 transporter.

Rahman F, Bordignon B, Culerrier R, Peiretti F, Spicuglia S, Djabali M, Landrier JF, Fontes M.

Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600506. Epub 2017 Feb 15.


Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.

Poggi M, Canault M, Favier M, Turro E, Saultier P, Ghalloussi D, Baccini V, Vidal L, Mezzapesa A, Chelghoum N, Mohand-Oumoussa B, Falaise C, Favier R, Ouwehand WH, Fiore M, Peiretti F, Morange PE, Saut N, Bernot D, Greinacher A, BioResource N, Nurden AT, Nurden P, Freson K, Trégouët DA, Raslova H, Alessi MC.

Haematologica. 2017 Feb;102(2):282-294. doi: 10.3324/haematol.2016.147694. Epub 2016 Sep 23.


Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform.

Stalin J, Harhouri K, Hubert L, Garrigue P, Nollet M, Essaadi A, Muller A, Foucault-Bertaud A, Bachelier R, Sabatier F, Pisano P, Peiretti F, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M.

Cardiovasc Res. 2016 Aug 1;111(3):240-51. doi: 10.1093/cvr/cvw096. Epub 2016 May 11.


The first intracellular loop of GLUT4 contains a retention motif.

Talantikite M, Berenguer M, Gonzalez T, Alessi MC, Poggi M, Peiretti F, Govers R.

J Cell Sci. 2016 Jun 1;129(11):2273-84. doi: 10.1242/jcs.183525. Epub 2016 Apr 27.


Erratum to: CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors.

Mones S, Gess B, Bordignon B, Altié A, Young P, Bihel F, Fraterno M, Peiretti F, Fontes M.

Orphanet J Rare Dis. 2016 Jan 25;11:6. doi: 10.1186/s13023-015-0354-2. No abstract available.


The Transcriptional Effects of PCB118 and PCB153 on the Liver, Adipose Tissue, Muscle and Colon of Mice: Highlighting of Glut4 and Lipin1 as Main Target Genes for PCB Induced Metabolic Disorders.

Mesnier A, Champion S, Louis L, Sauzet C, May P, Portugal H, Benbrahim K, Abraldes J, Alessi MC, Amiot-Carlin MJ, Peiretti F, Piccerelle P, Nalbone G, Villard PH.

PLoS One. 2015 Jun 18;10(6):e0128847. doi: 10.1371/journal.pone.0128847. eCollection 2015.


CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice.

Poggi M, Morin SO, Bastelica D, Govers R, Canault M, Bernot D, Georgelin O, Verdier M, Burcelin R, Olive D, Alessi MC, Peiretti F, Nunès JA.

Int J Obes (Lond). 2015 Jun;39(6):977-85. doi: 10.1038/ijo.2015.26. Epub 2015 Mar 16.


Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice.

Karkeni E, Marcotorchino J, Tourniaire F, Astier J, Peiretti F, Darmon P, Landrier JF.

Endocrinology. 2015 May;156(5):1782-93. doi: 10.1210/en.2014-1647. Epub 2015 Mar 2.


The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).

Kara I, Poggi M, Bonardo B, Govers R, Landrier JF, Tian S, Leibiger I, Day R, Creemers JW, Peiretti F.

J Biol Chem. 2015 Jan 30;290(5):2812-21. doi: 10.1074/jbc.M114.592543. Epub 2014 Dec 19.


Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool.

Rahman F, Al Frouh F, Bordignon B, Fraterno M, Landrier JF, Peiretti F, Fontes M.

Front Cell Dev Biol. 2014 Aug 7;2:29. doi: 10.3389/fcell.2014.00029. eCollection 2014.


Visfatin is involved in TNFα-mediated insulin resistance via an NAD(+)/Sirt1/PTP1B pathway in 3T3-L1 adipocytes.

Gouranton E, Romier B, Marcotorchino J, Tourniaire F, Astier J, Peiretti F, Landrier JF.

Adipocyte. 2014 Jul 1;3(3):180-9. doi: 10.4161/adip.28729. Epub 2014 Apr 4.


CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene.

Mones S, Bordignon B, Peiretti F, Landrier JF, Gess B, Bourguignon JJ, Bihel F, Fontés M.

Front Neurosci. 2014 Jun 13;8:151. doi: 10.3389/fnins.2014.00151. eCollection 2014.


Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA.

J Exp Med. 2014 Jun 30;211(7):1349-62. doi: 10.1084/jem.20130477. Epub 2014 Jun 23.

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