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Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

Degtyareva NP, Saini N, Sterling JF, Placentra VC, Klimczak LJ, Gordenin DA, Doetsch PW.

PLoS Biol. 2019 May 8;17(5):e3000263. doi: 10.1371/journal.pbio.3000263. eCollection 2019 May.


Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.

Limpose KL, Trego KS, Li Z, Leung SW, Sarker AH, Shah JA, Ramalingam SS, Werner EM, Dynan WS, Cooper PK, Corbett AH, Doetsch PW.

Nucleic Acids Res. 2018 May 18;46(9):4515-4532. doi: 10.1093/nar/gky162.


Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways.

Sha Y, Vartanian V, Owen N, Mengden Koon SJ, Calkins MJ, Thompson CS, Mirafzali Z, Mir S, Goldsmith LE, He H, Luo C, Brown SM, Doetsch PW, Kaempf A, Lim JY, McCullough AK, Lloyd RS.

Sci Rep. 2018 Jan 15;8(1):705. doi: 10.1038/s41598-017-17940-8.


Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.

Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Satola SW, Ramalingam SS, Curran WJ, Doetsch PW, Deng X.

J Clin Invest. 2018 Jan 2;128(1):500-516. doi: 10.1172/JCI92742. Epub 2017 Dec 11.


SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS.

Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008.


A Single Exposure to Low- or High-LET Radiation Induces Persistent Genomic Damage in Mouse Epithelial Cells In Vitro and in Lung Tissue.

Werner E, Wang Y, Doetsch PW.

Radiat Res. 2017 Oct;188(4):373-380. doi: 10.1667/RR14685.1. Epub 2017 Jul 28.


Genome-wide map of Apn1 binding sites under oxidative stress in Saccharomyces cerevisiae.

Morris LP, Conley AB, Degtyareva N, Jordan IK, Doetsch PW.

Yeast. 2017 Nov;34(11):447-458. doi: 10.1002/yea.3247. Epub 2017 Sep 26.


BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.

Limpose KL, Corbett AH, Doetsch PW.

DNA Repair (Amst). 2017 Aug;56:51-64. doi: 10.1016/j.dnarep.2017.06.007. Epub 2017 Jun 9. Review.


Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion.

Yang LL, Liu BC, Lu XY, Yan Y, Zhai YJ, Bao Q, Doetsch PW, Deng X, Thai TL, Alli AA, Eaton DC, Shen BZ, Ma HP.

Oncotarget. 2017 Jan 17;8(3):5123-5134. doi: 10.18632/oncotarget.14034.


Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.

Fan J, Lin R, Xia S, Chen D, Elf SE, Liu S, Pan Y, Xu H, Qian Z, Wang M, Shan C, Zhou L, Lei QY, Li Y, Mao H, Lee BH, Sudderth J, DeBerardinis RJ, Zhang G, Owonikoko T, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Kang S, Doetsch PW, Lonial S, Boggon TJ, Curran WJ, Chen J.

Mol Cell. 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014. Epub 2016 Nov 17.


Identification of SUMO modification sites in the base excision repair protein, Ntg1.

Swartzlander DB, McPherson AJ, Powers HR, Limpose KL, Kuiper EG, Degtyareva NP, Corbett AH, Doetsch PW.

DNA Repair (Amst). 2016 Dec;48:51-62. doi: 10.1016/j.dnarep.2016.10.011. Epub 2016 Oct 31.


Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells.

Petrova L, Gran C, Bjoras M, Doetsch PW.

PLoS One. 2016 Jun 30;11(6):e0158581. doi: 10.1371/journal.pone.0158581. eCollection 2016.


Evaluating biomarkers to model cancer risk post cosmic ray exposure.

Sridharan DM, Asaithamby A, Blattnig SR, Costes SV, Doetsch PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y, Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL, Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM.

Life Sci Space Res (Amst). 2016 Jun;9:19-47. doi: 10.1016/j.lssr.2016.05.004. Epub 2016 May 21. Review.


Robert J. Suhadolnik (1925-2016).

Doetsch PW.

J Interferon Cytokine Res. 2016 May;36(5):277-8. doi: 10.1089/jir.2016.29001.rjs. No abstract available.


ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.

Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS.

Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4.


Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells.

Werner E, Wang H, Doetsch PW.

Radiat Res. 2015 Dec;184(6):621-9. doi: 10.1667/RR14045.1. Epub 2015 Nov 18.


The current state of eukaryotic DNA base damage and repair.

Bauer NC, Corbett AH, Doetsch PW.

Nucleic Acids Res. 2015 Dec 2;43(21):10083-101. doi: 10.1093/nar/gkv1136. Epub 2015 Oct 30. Review.


HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells.

Marullo R, Werner E, Zhang H, Chen GZ, Shin DM, Doetsch PW.

Carcinogenesis. 2015 Nov;36(11):1397-406. doi: 10.1093/carcin/bgv126. Epub 2015 Sep 8.


Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli.

Morreall J, Kim A, Liu Y, Degtyareva N, Weiss B, Doetsch PW.

PLoS Genet. 2015 Aug 25;11(8):e1005477. doi: 10.1371/journal.pgen.1005477. eCollection 2015 Aug.


Bcl2 inhibition of mitochondrial DNA repair.

Xie M, Doetsch PW, Deng X.

BMC Cancer. 2015 Aug 13;15:586. doi: 10.1186/s12885-015-1594-1.

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