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Items: 1 to 20 of 84

1.

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia.

Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I.

Nat Commun. 2018 Sep 21;9(1):3839. doi: 10.1038/s41467-018-06069-5.

PMID:
30242258
2.

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ, Rowe HM.

Genome Res. 2018 Jun;28(6):836-845. doi: 10.1101/gr.228171.117. Epub 2018 May 4.

3.

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

Wang ECY, Pjechova M, Nightingale K, Vlahava VM, Patel M, Ruckova E, Forbes SK, Nobre L, Antrobus R, Roberts D, Fielding CA, Seirafian S, Davies J, Murrell I, Lau B, Wilkie GS, Suárez NM, Stanton RJ, Vojtesek B, Davison A, Lehner PJ, Weekes MP, Wilkinson GWG, Tomasec P.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4998-5003. doi: 10.1073/pnas.1720950115. Epub 2018 Apr 24.

PMID:
29691324
4.

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

Rhodes DA, Chen HC, Williamson JC, Hill A, Yuan J, Smith S, Rhodes H, Trowsdale J, Lehner PJ, Herrmann T, Eberl M.

Front Immunol. 2018 Apr 4;9:662. doi: 10.3389/fimmu.2018.00662. eCollection 2018.

5.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA.

EMBO Rep. 2018 May;19(5). pii: e45603. doi: 10.15252/embr.201745603. Epub 2018 Mar 8.

6.

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y.

Nat Commun. 2018 Feb 13;9(1):651. doi: 10.1038/s41467-018-03045-x.

7.

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA.

Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16.

8.

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

Stewart SE, Menzies SA, Popa SJ, Savinykh N, Petrunkina Harrison A, Lehner PJ, Moreau K.

J Cell Sci. 2017 Oct 1;130(19):3234-3247. doi: 10.1242/jcs.206425. Epub 2017 Aug 3.

9.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.

van de Weijer ML, Schuren ABC, van den Boomen DJH, Mulder A, Claas FHJ, Lehner PJ, Lebbink RJ, Wiertz EJHJ.

J Cell Sci. 2017 Sep 1;130(17):2883-2892. doi: 10.1242/jcs.206839. Epub 2017 Jul 25.

10.

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ.

Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5.

11.

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

De Angelis Rigotti F, De Gassart A, Pforr C, Cano F, N'Guessan P, Combes A, Camossetto V, Lehner PJ, Pierre P, Gatti E.

Immunol Cell Biol. 2017 Oct;95(9):753-764. doi: 10.1038/icb.2017.44. Epub 2017 May 31.

PMID:
28559542
12.

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.

Fielding CA, Weekes MP, Nobre LV, Ruckova E, Wilkie GS, Paulo JA, Chang C, Suárez NM, Davies JA, Antrobus R, Stanton RJ, Aicheler RJ, Nichols H, Vojtesek B, Trowsdale J, Davison AJ, Gygi SP, Tomasec P, Lehner PJ, Wilkinson GW.

Elife. 2017 Feb 10;6. pii: e22206. doi: 10.7554/eLife.22206.

13.

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.

Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27.

14.

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Greenwood EJ, Matheson NJ, Wals K, van den Boomen DJ, Antrobus R, Williamson JC, Lehner PJ.

Elife. 2016 Sep 30;5. pii: e18296. doi: 10.7554/eLife.18296.

15.

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ.

Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050.

16.

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M.

Nat Cell Biol. 2016 Sep;18(9):979-92. doi: 10.1038/ncb3397. Epub 2016 Aug 15.

17.

Manipulation of immunometabolism by HIV-accessories to the crime?

Matheson NJ, Greenwood EJ, Lehner PJ.

Curr Opin Virol. 2016 Aug;19:65-70. doi: 10.1016/j.coviro.2016.06.014. Epub 2016 Jul 21. Review.

PMID:
27448768
18.

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ.

Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786.

19.

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

Rapiteanu R, Davis LJ, Williamson JC, Timms RT, Paul Luzio J, Lehner PJ.

Traffic. 2016 Aug;17(8):940-58. doi: 10.1111/tra.12409. Epub 2016 May 25.

20.

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Timms RT, Tchasovnikarova IA, Lehner PJ.

Bioessays. 2016 Apr;38(4):333-43. doi: 10.1002/bies.201500184. Epub 2016 Feb 8. Review.

PMID:
26853531

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