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Items: 1 to 20 of 158

1.

BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation.

Lempiäinen JK, Manjur ABMK, Malinen M, Ketola K, Niskanen EA, Palvimo JJ.

Oncogene. 2020 Jan 10. doi: 10.1038/s41388-020-1153-3. [Epub ahead of print]

PMID:
31925334
2.

A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin.

Tolonen JP, Heikkilä M, Malinen M, Lee HM, Palvimo JJ, Wei GH, Myllyharju J.

Cell Mol Life Sci. 2019 Nov 25. doi: 10.1007/s00018-019-03387-9. [Epub ahead of print]

PMID:
31768607
3.

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

Dendoncker K, Timmermans S, Vandewalle J, Eggermont M, Lempiäinen J, Paakinaho V, Van Hamme E, Dewaele S, Vandevyver S, Ballegeer M, Souffriau J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, Beyaert R, De Bosscher K, Palvimo JJ, Van Montagu M, Libert C.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12942-12951. doi: 10.1073/pnas.1821565116. Epub 2019 Jun 10. Erratum in: Proc Natl Acad Sci U S A. 2019 Jul 22;:.

4.

IRF2BP2 modulates the crosstalk between glucocorticoid and TNF signaling.

Manjur ABMK, Lempiäinen JK, Malinen M, Palvimo JJ, Niskanen EA.

J Steroid Biochem Mol Biol. 2019 Sep;192:105382. doi: 10.1016/j.jsbmb.2019.105382. Epub 2019 May 28.

PMID:
31145973
5.

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.

Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Niskanen EA, Korhonen H, Laiho A, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo JJ.

Nat Commun. 2019 Feb 15;10(1):777. doi: 10.1038/s41467-019-08730-z.

6.

Androgen receptor SUMOylation regulates bone mass in male mice.

Wu J, Movérare-Skrtic S, Zhang FP, Koskela A, Tuukkanen J, Palvimo JJ, Sipilä P, Poutanen M, Ohlsson C.

Mol Cell Endocrinol. 2019 Jan 5;479:117-122. doi: 10.1016/j.mce.2018.09.008. Epub 2018 Sep 24.

7.

Response: Commentary: Analysis of SUMO1-conjugation at synapses.

Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M.

Front Cell Neurosci. 2018 May 1;12:117. doi: 10.3389/fncel.2018.00117. eCollection 2018. No abstract available.

8.

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

Lempiäinen JK, Niskanen EA, Vuoti KM, Lampinen RE, Göös H, Varjosalo M, Palvimo JJ.

Mol Cell Proteomics. 2017 Aug;16(8):1462-1474. doi: 10.1074/mcp.M117.067488. Epub 2017 Jun 13.

9.

Analysis of SUMO1-conjugation at synapses.

Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M.

Elife. 2017 Jun 9;6. pii: e26338. doi: 10.7554/eLife.26338.

10.

Chromatin SUMOylation in heat stress: To protect, pause and organise?: SUMO stress response on chromatin.

Niskanen EA, Palvimo JJ.

Bioessays. 2017 Jun;39(6). doi: 10.1002/bies.201600263. Epub 2017 Apr 25. Review.

PMID:
28440894
11.

ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.

Anttonen AK, Laari A, Kousi M, Yang YJ, Jääskeläinen T, Somer M, Siintola E, Jakkula E, Muona M, Tegelberg S, Lönnqvist T, Pihko H, Valanne L, Paetau A, Lun MP, Hästbacka J, Kopra O, Joensuu T, Katsanis N, Lehtinen MK, Palvimo JJ, Lehesjoki AE.

Brain. 2017 May 1;140(5):1267-1279. doi: 10.1093/brain/awx040.

PMID:
28335020
12.

Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-κB cistrome to reprogram the prostate cancer cell transcriptome.

Malinen M, Niskanen EA, Kaikkonen MU, Palvimo JJ.

Nucleic Acids Res. 2017 Jan 25;45(2):619-630. doi: 10.1093/nar/gkw855. Epub 2016 Sep 26.

13.

Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets.

Toropainen S, Niskanen EA, Malinen M, Sutinen P, Kaikkonen MU, Palvimo JJ.

Sci Rep. 2016 Sep 19;6:33510. doi: 10.1038/srep33510.

14.

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene.

Känsäkoski J, Jääskeläinen J, Jääskeläinen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, Raivio T.

Sci Rep. 2016 Sep 9;6:32819. doi: 10.1038/srep32819.

15.

SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling.

Yan Y, Ollila S, Wong IPL, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP.

Nat Commun. 2015 Nov 30;6:8979. doi: 10.1038/ncomms9979.

16.

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly.

Eisenhardt N, Chaugule VK, Koidl S, Droescher M, Dogan E, Rettich J, Sutinen P, Imanishi SY, Hofmann K, Palvimo JJ, Pichler A.

Nat Struct Mol Biol. 2015 Dec;22(12):959-67. doi: 10.1038/nsmb.3114. Epub 2015 Nov 2.

PMID:
26524493
17.

Global SUMOylation on active chromatin is an acute heat stress response restricting transcription.

Niskanen EA, Malinen M, Sutinen P, Toropainen S, Paakinaho V, Vihervaara A, Joutsen J, Kaikkonen MU, Sistonen L, Palvimo JJ.

Genome Biol. 2015 Jul 28;16:153. doi: 10.1186/s13059-015-0717-y.

18.

Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells.

Malinen M, Toropainen S, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ.

Mol Cell Endocrinol. 2015 Oct 15;414:91-8. doi: 10.1016/j.mce.2015.07.024. Epub 2015 Jul 26.

PMID:
26219822
19.

Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies.

Moilanen AM, Riikonen R, Oksala R, Ravanti L, Aho E, Wohlfahrt G, Nykänen PS, Törmäkangas OP, Palvimo JJ, Kallio PJ.

Sci Rep. 2015 Jul 3;5:12007. doi: 10.1038/srep12007.

20.

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells.

Lindqvist J, Imanishi SY, Torvaldson E, Malinen M, Remes M, Örn F, Palvimo JJ, Eriksson JE.

Mol Biol Cell. 2015 Jun 1;26(11):1971-84. doi: 10.1091/mbc.E14-12-1634. Epub 2015 Apr 7.

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