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Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward.

Sagheddu C, Scherma M, Congiu M, Fadda P, Carta G, Banni S, Wood JT, Makriyannis A, Malamas MS, Pistis M.

Neuropharmacology. 2018 Nov 12;144:327-336. doi: 10.1016/j.neuropharm.2018.11.013. [Epub ahead of print]


Satiety Factors Oleoylethanolamide, Stearoylethanolamide, and Palmitoylethanolamide in Mother's Milk Are Strongly Associated with Infant Weight at Four Months of Age-Data from the Odense Child Cohort.

Bruun S, Gouveia-Figueira S, Domellöf M, Husby S, Neergaard Jacobsen L, Michaelsen KF, Fowler CJ, Zachariassen G.

Nutrients. 2018 Nov 13;10(11). pii: E1747. doi: 10.3390/nu10111747.


Characterization of the endocannabinoid system in subcutaneous adipose tissue in periparturient dairy cows and its association to metabolic profiles.

Zachut M, Kra G, Moallem U, Livshitz L, Levin Y, Udi S, Nemirovski A, Tam J.

PLoS One. 2018 Nov 7;13(11):e0205996. doi: 10.1371/journal.pone.0205996. eCollection 2018.


Role of palmitoylethanolamide (PEA) in depression: Translational evidence.

De Gregorio D, Manchia M, Carpiniello B, Valtorta F, Nobile M, Gobbi G, Comai S.

J Affect Disord. 2018 Oct 25. pii: S0165-0327(18)31599-4. doi: 10.1016/j.jad.2018.10.117. [Epub ahead of print] Review.


Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients: a preliminary randomized double-blind controlled trial.

Ottaviani G, Rupel K, Gobbo M, Poropat A, Zoi V, Faraon M, Di Lenarda R, Biasotto M.

Clin Oral Investig. 2018 Oct 25. doi: 10.1007/s00784-018-2720-7. [Epub ahead of print]


Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation.

Rinne P, Guillamat-Prats R, Rami M, Bindila L, Ring L, Lyytikäinen LP, Raitoharju E, Oksala N, Lehtimäki T, Weber C, van der Vorst EPC, Steffens S.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2562-2575. doi: 10.1161/ATVBAHA.118.311185.


Molecular mechanism of activation of the immunoregulatory amidase NAAA.

Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10032-E10040. doi: 10.1073/pnas.1811759115. Epub 2018 Oct 9.


2-arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction.

Schloss MJ, Horckmans M, Guillamat-Prats R, Hering D, Lauer E, Lenglet S, Weber C, Thomas A, Steffens S.

Cardiovasc Res. 2018 Sep 28. doi: 10.1093/cvr/cvy242. [Epub ahead of print]


Endocannabinoids and related N-acylethanolamines: biological activities and metabolism.

Tsuboi K, Uyama T, Okamoto Y, Ueda N.

Inflamm Regen. 2018 Oct 1;38:28. doi: 10.1186/s41232-018-0086-5. eCollection 2018. Review.


Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.

Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S, Luongo L.

Neurobiol Dis. 2019 Jan;121:106-119. doi: 10.1016/j.nbd.2018.09.023. Epub 2018 Sep 25.


Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia.

Portavella M, Rodriguez-Espinosa N, Galeano P, Blanco E, Romero JI, Holubiec MI, Rodriguez de Fonseca F, Fernández-Espejo E.

Cannabis Cannabinoid Res. 2018 Sep 19;3(1):171-178. doi: 10.1089/can.2018.0013. eCollection 2018.


Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety.

Danandeh A, Vozella V, Lim J, Oveisi F, Ramirez GL, Mears D, Wynn G, Piomelli D.

Psychopharmacology (Berl). 2018 Nov;235(11):3211-3221. doi: 10.1007/s00213-018-5020-7. Epub 2018 Sep 24.


Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush.

Gugliandolo E, D'amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R.

J Neuroinflammation. 2018 Sep 14;15(1):264. doi: 10.1186/s12974-018-1303-5.


Palmitoylethanolamide counteracts autistic-like behaviours in BTBR T+tf/J mice: Contribution of central and peripheral mechanisms.

Cristiano C, Pirozzi C, Coretti L, Cavaliere G, Lama A, Russo R, Lembo F, Mollica MP, Meli R, Calignano A, Mattace Raso G.

Brain Behav Immun. 2018 Sep 5. pii: S0889-1591(18)30548-8. doi: 10.1016/j.bbi.2018.09.003. [Epub ahead of print]


Micronized palmitoylethanolamide reduces joint pain and glial cell activation.

Bartolucci ML, Marini I, Bortolotti F, Impellizzeri D, Di Paola R, Bruschetta G, Crupi R, Portelli M, Militi A, Oteri G, Esposito E, Cuzzocrea S.

Inflamm Res. 2018 Oct;67(10):891-901. doi: 10.1007/s00011-018-1179-y. Epub 2018 Aug 18.


Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure.

Heinitz S, Basolo A, Piomelli D, Krakoff J, Piaggi P.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3757-3766. doi: 10.1210/jc.2018-00780.


Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia.

Holubiec MI, Romero JI, Suárez J, Portavella M, Fernández-Espejo E, Blanco E, Galeano P, de Fonseca FR.

Psychopharmacology (Berl). 2018 Oct;235(10):2929-2945. doi: 10.1007/s00213-018-4982-9. Epub 2018 Jul 29.


Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.

Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N.

Front Pharmacol. 2018 Jul 13;9:709. doi: 10.3389/fphar.2018.00709. eCollection 2018.


Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism.

Fanelli F, Mezzullo M, Repaci A, Belluomo I, Ibarra Gasparini D, Di Dalmazi G, Mastroroberto M, Vicennati V, Gambineri A, Morselli-Labate AM, Pasquali R, Pagotto U.

Mol Metab. 2018 Jun 6. pii: S2212-8778(18)30393-4. doi: 10.1016/j.molmet.2018.06.002. [Epub ahead of print]

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