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Items: 1 to 20 of 29


Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection.

Swale C, Bougdour A, Gnahoui-David A, Tottey J, Georgeault S, Laurent F, Palencia A, Hakimi MA.

Sci Transl Med. 2019 Nov 6;11(517). pii: eaax7161. doi: 10.1126/scitranslmed.aax7161.


Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4.

Iglesias-Bexiga M, Palencia A, Corbi-Verge C, Martin-Malpartida P, Blanco FJ, Macias MJ, Cobos ES, Luque I.

Sci Rep. 2019 Oct 21;9(1):15076. doi: 10.1038/s41598-019-50701-3.


Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy.

Delaforge E, Kragelj J, Tengo L, Palencia A, Milles S, Bouvignies G, Salvi N, Blackledge M, Jensen MR.

J Am Chem Soc. 2018 Jan 24;140(3):1148-1158. doi: 10.1021/jacs.7b12407. Epub 2018 Jan 11.


Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.

Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, Gruic-Sovulj I.

J Mol Biol. 2018 Jan 5;430(1):1-16. doi: 10.1016/j.jmb.2017.10.024. Epub 2017 Oct 27.


Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites.

Sindikubwabo F, Ding S, Hussain T, Ortet P, Barakat M, Baumgarten S, Cannella D, Palencia A, Bougdour A, Belmudes L, Couté Y, Tardieux I, Botté CY, Scherf A, Hakimi MA.

Elife. 2017 Nov 4;6. pii: e29391. doi: 10.7554/eLife.29391.


Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA.

EMBO Mol Med. 2017 Mar;9(3):385-394. doi: 10.15252/emmm.201607370.


Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.

Pellegrini E, Palencia A, Braun L, Kapp U, Bougdour A, Belrhali H, Bowler MW, Hakimi MA.

Structure. 2017 Jan 3;25(1):16-26. doi: 10.1016/j.str.2016.10.011. Epub 2016 Nov 23.


Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J.

Nat Commun. 2016 Oct 7;7:12928. doi: 10.1038/ncomms12928.


Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.


Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct.


Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug.


Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate.

Aleksandrov A, Palencia A, Cusack S, Field M.

J Phys Chem B. 2016 May 19;120(19):4388-98. doi: 10.1021/acs.jpcb.6b02387. Epub 2016 May 10.


Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.

Zhao H, Palencia A, Seiradake E, Ghaemi Z, Cusack S, Luthey-Schulten Z, Martinis S.

ACS Chem Biol. 2015 Oct 16;10(10):2277-85. doi: 10.1021/acschembio.5b00291. Epub 2015 Jul 31.


Structure and dynamics of the MKK7-JNK signaling complex.

Kragelj J, Palencia A, Nanao MH, Maurin D, Bouvignies G, Blackledge M, Jensen MR.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3409-14. doi: 10.1073/pnas.1419528112. Epub 2015 Mar 3.


Biochemical and biophysical characterization of the selenium-binding and reducing site in Arabidopsis thaliana homologue to mammals selenium-binding protein 1.

Schild F, Kieffer-Jaquinod S, Palencia A, Cobessi D, Sarret G, Zubieta C, Jourdain A, Dumas R, Forge V, Testemale D, Bourguignon J, Hugouvieux V.

J Biol Chem. 2014 Nov 14;289(46):31765-76. doi: 10.1074/jbc.M114.571208. Epub 2014 Oct 1.


The physiological target for LeuRS translational quality control is norvaline.

Cvetesic N, Palencia A, Halasz I, Cusack S, Gruic-Sovulj I.

EMBO J. 2014 Aug 1;33(15):1639-53. doi: 10.15252/embj.201488199. Epub 2014 Jun 16.


Crystal structure of mouse mu-crystallin complexed with NADPH and the T3 thyroid hormone.

Borel F, Hachi I, Palencia A, Gaillard MC, Ferrer JL.

FEBS J. 2014 Mar;281(6):1598-612. doi: 10.1111/febs.12726. Epub 2014 Feb 10.


The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains.

Benoit MP, Imbert L, Palencia A, Pérard J, Ebel C, Boisbouvier J, Plevin MJ.

Nucleic Acids Res. 2013 Apr;41(7):4241-52. doi: 10.1093/nar/gkt086. Epub 2013 Feb 21.


Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens.

Li L, Palencia A, Lukk T, Li Z, Luthey-Schulten ZA, Cusack S, Martinis SA, Boniecki MT.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3817-22. doi: 10.1073/pnas.1218374110. Epub 2013 Feb 19.


Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase.

Chopra S, Palencia A, Virus C, Tripathy A, Temple BR, Velazquez-Campoy A, Cusack S, Reader JS.

Nat Commun. 2013;4:1417. doi: 10.1038/ncomms2421.


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