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Year Number of Results
1983 1
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1993 1
1995 1
1996 3
1998 1
2000 2
2001 3
2002 1
2003 2
2006 1
2007 1
2008 4
2009 2
2010 2
2011 1
2012 3
2013 3
2014 3
2015 1
2016 1
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2018 3
2019 6
2020 3
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Page 1
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
Johannes JW, Balazs A, Barratt D, Bista M, Chuba MD, Cosulich S, Critchlow SE, Degorce SL, Di Fruscia P, Edmondson SD, Embrey K, Fawell S, Ghosh A, Gill SJ, Gunnarsson A, Hande SM, Heightman TD, Hemsley P, Illuzzi G, Lane J, Larner C, Leo E, Liu L, Madin A, Martin S, McWilliams L, O'Connor MJ, Orme JP, Pachl F, Packer MJ, Pei X, Pike A, Schimpl M, She H, Staniszewska AD, Talbot V, Underwood E, Varnes JG, Xue L, Yao T, Zhang K, Zhang AX, Zheng X. Johannes JW, et al. Among authors: packer mj. J Med Chem. 2021 Oct 14;64(19):14498-14512. doi: 10.1021/acs.jmedchem.1c01012. Epub 2021 Sep 27. J Med Chem. 2021. PMID: 34570508
Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.
O' Donovan DH, Baker D, Ciotta G, Degorce SL, Demanze S, Dockerill M, Escudero-Ibarz L, Ireland L, Mao Y, Packer MJ, Robinson J, Scarfe G, Tang H, Valge-Archer V. O' Donovan DH, et al. Among authors: packer mj. Bioorg Med Chem Lett. 2023 Nov 15;96:129518. doi: 10.1016/j.bmcl.2023.129518. Epub 2023 Oct 12. Bioorg Med Chem Lett. 2023. PMID: 37838344
Noncovalent Assembly of.
Hunter CA, Low CM, Packer MJ, Spey SE, Vinter JG, Vysotsky MO, Zonta C. Hunter CA, et al. Among authors: packer mj. Angew Chem Int Ed Engl. 2001 Jul 16;40(14):2678-2682. Angew Chem Int Ed Engl. 2001. PMID: 11458371 No abstract available.
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW. Johannes JW, et al. Among authors: packer mj. ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 9. ACS Med Chem Lett. 2016. PMID: 28197319 Free PMC article.
54 results