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66 results

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Page 1
PTH2R is related to cell proliferation and migration in ovarian cancer: a multi-omics analysis of bioinformatics and experiments.
Xiaowei W, Tong L, Yanjun Q, Lili F. Xiaowei W, et al. Cancer Cell Int. 2022 Apr 11;22(1):148. doi: 10.1186/s12935-022-02566-2. Cancer Cell Int. 2022. PMID: 35410353 Free PMC article.
Finally, experimental verification showed that PTH2R gene was highly expressed in ovarian cancer, and PTH2R gene was involved in the proliferation, invasion and metastasis of ovarian cancer cells. CONCLUSIONS: After experimental verification, we found that knocking …
Finally, experimental verification showed that PTH2R gene was highly expressed in ovarian cancer, and PTH2R gene was involved …
Conserved class B GPCR activation by a biased intracellular agonist.
Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE. Zhao LH, et al. Nature. 2023 Sep;621(7979):635-641. doi: 10.1038/s41586-023-06467-w. Epub 2023 Jul 31. Nature. 2023. PMID: 37524305
The residues that make up the PCO371-binding pocket are conserved in class B GPCRs, and a single alteration in PTH2R and two residue alterations in GLP1R convert these receptors to respond to PCO371. ...
The residues that make up the PCO371-binding pocket are conserved in class B GPCRs, and a single alteration in PTH2R and two residue …
Asbestos-Induced Lung Cancer-Associated SNP rs13383928 Regulates PTH2R Expression in Lung Tissue.
Meng YQ, Shi Q, Zhu SJ, He GH, Zhang SJ, Sun C. Meng YQ, et al. Hum Hered. 2021 Feb 5:1-5. doi: 10.1159/000513291. Online ahead of print. Hum Hered. 2021. PMID: 33550301
The following dual luciferase assay disclosed that the T allele of rs13383928 presented significantly higher enhancer activity than G in lung cells, thus verifying that this SNP was functional in the lung. Through chromosome conformation capture, the PTH2R (parathyroid hor …
The following dual luciferase assay disclosed that the T allele of rs13383928 presented significantly higher enhancer activity than G in lun …
Variation in the PTH2R gene is associated with age-related degenerative changes in the lumbar spine.
Åkesson K, Tenne M, Gerdhem P, Luthman H, McGuigan FE. Åkesson K, et al. J Bone Miner Metab. 2015 Jan;33(1):9-15. doi: 10.1007/s00774-013-0550-x. Epub 2013 Dec 31. J Bone Miner Metab. 2015. PMID: 24378925
Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image for apparent degenerative manifestations. Six SNPs in PTH and 3 SNPs each in PTH1R, PTH2R and PTHLH were analysed. Among women with …
Lumbar spine BMD was assessed by dual energy X-ray absorptiometry (DXA) and each individual vertebra was evaluated visually on the DXA image …
Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2).
Keller D, Tsuda MC, Usdin TB, Dobolyi A. Keller D, et al. J Neuroendocrinol. 2022 Sep;34(9):e13130. doi: 10.1111/jne.13130. Epub 2022 May 2. J Neuroendocrinol. 2022. PMID: 35499975 Free PMC article. Review.
Tuberoinfundibular peptide of 39 residues (TIP39) acts via its endogenous class B G-protein coupled receptorthe parathyroid hormone 2 receptor (PTH2R). Hence, it is also known as parathyroid hormone 2. The peptide is expressed in the brain by a small number of neurons with …
Tuberoinfundibular peptide of 39 residues (TIP39) acts via its endogenous class B G-protein coupled receptorthe parathyroid hormone 2 recept …
New Mechanisms of ECM Production during Wound Healing: A Role for Parathyroid Hormone 2 Receptor Signaling.
Wilgus TA. Wilgus TA. J Invest Dermatol. 2017 Aug;137(8):1617-1619. doi: 10.1016/j.jid.2017.05.001. J Invest Dermatol. 2017. PMID: 28735615 Free article. Review.
TIP39-PTH2R signaling induced decorin expression, which may explain the beneficial effects of PTH2R signaling on healing. These studies identify a novel role for PTH2R signaling in extracellular matrix production....
TIP39-PTH2R signaling induced decorin expression, which may explain the beneficial effects of PTH2R signaling on healing. Thes …
The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation.
Sato E, Muto J, Zhang LJ, Adase CA, Sanford JA, Takahashi T, Nakatsuji T, Usdin TB, Gallo RL. Sato E, et al. J Invest Dermatol. 2016 Jul;136(7):1449-1459. doi: 10.1016/j.jid.2016.02.814. Epub 2016 Mar 19. J Invest Dermatol. 2016. PMID: 27000502 Free PMC article.
TIP39 and PTH2R mRNA and protein were detectable in both human and mouse skin, and in cultured keratinocytes and adipocytes. TIP39 was observed in the basal layer of human skin, whereas PTH2R was detected in the spinous to granular layer. The subcellular localizatio …
TIP39 and PTH2R mRNA and protein were detectable in both human and mouse skin, and in cultured keratinocytes and adipocytes. TIP39 wa …
Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development.
Bhattacharya P, Yan YL, Postlethwait J, Rubin DA. Bhattacharya P, et al. J Endocrinol. 2011 Nov;211(2):187-200. doi: 10.1530/JOE-10-0439. Epub 2011 Aug 31. J Endocrinol. 2011. PMID: 21880859 Free PMC article.
In mammals, parathyroid hormone (PTH), secreted by parathyroid glands, increases calcium levels in the blood from reservoirs in bone. While mammals have two PTH receptor genes, PTH1R and PTH2R, zebrafish has three receptors, pth1r, pth2r, and pth3r. PTH can activate …
In mammals, parathyroid hormone (PTH), secreted by parathyroid glands, increases calcium levels in the blood from reservoirs in bone. While …
Clinical Impact of Switching to Ceritinib After Severe AEs Related to Crizotinib/Alectinib in a Novel PTH2R-ALK Fusion Lung Adenocarcinoma: A Case Report.
Shen G, Du Y, Shen J, Zhang J, Xia X, Huang M, Shen W. Shen G, et al. Onco Targets Ther. 2021 Dec 23;14:5471-5475. doi: 10.2147/OTT.S340984. eCollection 2021. Onco Targets Ther. 2021. PMID: 34992382 Free PMC article.
Here, we describe a male patient with stage IV lung adenocarcinoma who carried a novel PTH2R-ALK fusion identified by next-generation sequencing (NGS). ...Our findings offer valuable information for the safety management of NSCLC patients with a novel PTH2R-ALK fusi …
Here, we describe a male patient with stage IV lung adenocarcinoma who carried a novel PTH2R-ALK fusion identified by next-generation …
The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms.
Dobolyi A, Palkovits M, Usdin TB. Dobolyi A, et al. Prog Neurobiol. 2010 Jan 11;90(1):29-59. doi: 10.1016/j.pneurobio.2009.10.017. Epub 2009 Oct 24. Prog Neurobiol. 2010. PMID: 19857544 Free PMC article. Review.
Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R). The TIP39-PTH2R system is a unique neuropeptide-receptor system whose localization and fun …
Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled para …
66 results