Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 1
1994 2
1995 2
1996 2
1997 2
1998 4
1999 2
2000 4
2001 5
2002 2
2004 9
2005 2
2006 8
2007 12
2008 9
2009 4
2010 7
2011 20
2012 11
2013 23
2014 25
2015 31
2016 23
2017 29
2018 33
2019 38
2020 42
2021 48
2022 45
2023 47
2024 17

Text availability

Article attribute

Article type

Publication date

Search Results

460 results

Results by year

Filters applied: . Clear all
Page 1
PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression.
Lee KW, Yeo SY, Gong JR, Koo OJ, Sohn I, Lee WY, Kim HC, Yun SH, Cho YB, Choi MA, An S, Kim J, Sung CO, Cho KH, Kim SH. Lee KW, et al. Nat Commun. 2022 May 19;13(1):2793. doi: 10.1038/s41467-022-30484-4. Nat Commun. 2022. PMID: 35589735 Free PMC article.
PRRX1 orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. ...This study reveals CAF subpopulations based on super-enhancer profiles including PRRX1. Therefore, mTFs, includi …
PRRX1 orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-en …
Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice.
Liu H, Li P, Zhang S, Xiang J, Yang R, Liu J, Shafiquzzaman M, Biswas S, Wei Z, Zhang Z, Zhou X, Yin F, Xie Y, Goff SP, Chen L, Li B. Liu H, et al. Nat Genet. 2022 Dec;54(12):1946-1958. doi: 10.1038/s41588-022-01227-4. Epub 2022 Dec 1. Nat Genet. 2022. PMID: 36456880
Single-cell profiling reveals the cycling and multipotent nature of Prrx1-expressing cells and the stemness of these cells is further validated by transplantation assays. Moreover, we identify the cell surface markers for Prrx1-expressing stem cells and show that th …
Single-cell profiling reveals the cycling and multipotent nature of Prrx1-expressing cells and the stemness of these cells is further …
PRRX1(+)MSCs Enhance Mandibular Regeneration during Distraction Osteogenesis.
Jiang WD, Zhu PQ, Zhang T, Liao FC, Jiang PP, Zhou N, Wang XD, Huang XP. Jiang WD, et al. J Dent Res. 2023 Aug;102(9):1058-1068. doi: 10.1177/00220345231176522. Epub 2023 Jun 30. J Dent Res. 2023. PMID: 37387366
Interestingly, 2 subpopulations in PRRX1(+)MSCs in the DO group were found to express the marker of neural crest cells (NCCs) and were associated with the process of epithelial-mesenchymal transition. ...In addition, the ability of osteogenesis, cell migration, and prolife …
Interestingly, 2 subpopulations in PRRX1(+)MSCs in the DO group were found to express the marker of neural crest cells (NCCs) and wer …
The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition.
Du W, Liu X, Yang M, Wang W, Sun J. Du W, et al. Onco Targets Ther. 2021 Jul 16;14:4223-4229. doi: 10.2147/OTT.S316102. eCollection 2021. Onco Targets Ther. 2021. PMID: 34295164 Free PMC article. Review.
PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. ...PRRX1 is not only closely related to the tumor cell stemness but also involved in miRNA regulation of EMT. ...
PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. ...PRRX1 is no …
PRRX1 promotes malignant properties in human osteosarcoma.
Joko R, Yamada D, Nakamura M, Yoshida A, Takihira S, Takao T, Lu M, Sato K, Ito T, Kunisada T, Nakata E, Ozaki T, Takarada T. Joko R, et al. Transl Oncol. 2021 Jan;14(1):100960. doi: 10.1016/j.tranon.2020.100960. Epub 2020 Dec 9. Transl Oncol. 2021. PMID: 33395745 Free PMC article.
Paired related homeobox 1 (PRRX1) is a marker of limb bud mesenchymal cells, and deficiency of p53 or Rb in Prrx1-positive cells induces osteosarcoma in several mouse models. However, the regulatory roles of PRRX1 in human osteosarcoma have not been defined. …
Paired related homeobox 1 (PRRX1) is a marker of limb bud mesenchymal cells, and deficiency of p53 or Rb in Prrx1-positive cel …
PRRX1/FOXM1 reduces gemcitabin-induced cytotoxicity by regulating autophagy in bladder cancer.
Huang X, Huang W, Wu K, Lin Q, Chen G. Huang X, et al. Transl Androl Urol. 2022 Aug;11(8):1116-1129. doi: 10.21037/tau-22-415. Transl Androl Urol. 2022. PMID: 36092834 Free PMC article.
However, the function of PRRX1 in BC remains poorly understood. The aim of our study is to explore the role of PRRX1 in BC progression. ...PRRX1 accelerated the viability and hindered the apoptosis of BC cells. ...
However, the function of PRRX1 in BC remains poorly understood. The aim of our study is to explore the role of PRRX1 in BC pro …
The emerging PRRX1-NCOA fibroblastic neoplasm: a combined reappraisal of published tumors and two new cases.
Chen CH, Chang KC, Chuang CH, Fu JT, Huang HY. Chen CH, et al. Virchows Arch. 2022 Jul;481(1):111-116. doi: 10.1007/s00428-021-03219-x. Epub 2021 Oct 14. Virchows Arch. 2022. PMID: 34647172 Review.
Nuclear receptor coactivator (NCOA) family gene fusions have been increasingly discovered in diverse mesenchymal neoplasms, while PRRX1-NCOA-fused fibroblastic tumors still remain insufficiently characterized. ...Review of published and current cases highlights a striking …
Nuclear receptor coactivator (NCOA) family gene fusions have been increasingly discovered in diverse mesenchymal neoplasms, while PRRX1 …
PRRX1 deficiency induces mesenchymal-epithelial transition through PITX2/miR-200-dependent SLUG/CTNNB1 regulation in hepatocellular carcinoma.
Chen W, Wu J, Shi W, Zhang G, Chen X, Ji A, Wang Z, Wu J, Jiang C. Chen W, et al. Cancer Sci. 2021 Jun;112(6):2158-2172. doi: 10.1111/cas.14853. Epub 2021 Apr 8. Cancer Sci. 2021. PMID: 33587761 Free PMC article.
In this study, we performed a systematic, mechanistic study regarding the role of PRRX1 in MET of HCC. We observed PRRX1 downregulation in HCC tissues, which correlated with early metastasis and short overall survival. ...PRRX1 protein levels reversely correl …
In this study, we performed a systematic, mechanistic study regarding the role of PRRX1 in MET of HCC. We observed PRRX1 downr …
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Zhong L, Tan W, Yang Q, Zou Z, Zhou R, Huang Y, Qiu Z, Zheng K, Huang Z. Zhong L, et al. J Gastrointest Oncol. 2022 Dec;13(6):2989-3008. doi: 10.21037/jgo-22-1137. J Gastrointest Oncol. 2022. PMID: 36636075 Free PMC article.
Previous research has revealed the stimulatory role of paired related homeobox 1 (PRRX1) on CRC metastasis. However, the role of PRRX1 in stemness acquirement and chemoresistance of CRC is still not clear. ...Inhibiting the expression of IL-6 dramatically eliminated …
Previous research has revealed the stimulatory role of paired related homeobox 1 (PRRX1) on CRC metastasis. However, the role of P …
PRRX1 Is a Novel Prognostic Biomarker and Facilitates Tumor Progression Through Epithelial-Mesenchymal Transition in Uveal Melanoma.
Meng Z, Chen Y, Wu W, Yan B, Zhang L, Chen H, Meng Y, Liang Y, Yao X, Luo J. Meng Z, et al. Front Immunol. 2022 Feb 25;13:754645. doi: 10.3389/fimmu.2022.754645. eCollection 2022. Front Immunol. 2022. PMID: 35281030 Free PMC article.
High PRRX1 expression was associated with poorer overall survival (OS) and metastasis-free survival (MFS) in UM patients. ...Taken together, these findings indicated that increased PRRX1 expression is independently a prognostic factor of poorer OS and MFS in patient …
High PRRX1 expression was associated with poorer overall survival (OS) and metastasis-free survival (MFS) in UM patients. ...Taken to …
460 results