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Biochem Biophys Res Commun. 2014 Jul 18;450(1):234-9. doi: 10.1016/j.bbrc.2014.05.095. Epub 2014 May 27.

Influenza entry pathways in polarized MDCK cells.

Author information

1
Department of Microbiology & Immunology, Cornell University, Ithaca, NY 14853, USA.
2
Department of Microbiology & Immunology, Cornell University, Ithaca, NY 14853, USA. Electronic address: grw7@cornell.edu.

Abstract

In non-polarized cell culture models, influenza virus has been shown to enter host cells via multiple endocytic pathways, including classical clathrin-mediated endocytic routes (CME), clathrin- and caveolae-independent routes and macropinocytosis. However, little is known about the entry route of influenza virus in differentiated epithelia, in vivo site of infection for influenza virus. Here, we show that in polarized Madin-Darby canine kidney type II (MDCK II) cells, influenza virus has a specific utilization of the clathrin-mediated endocytic pathway and requires Eps15 for host cell entry.

KEYWORDS:

Clathrin; Influenza virus; Polarized cell; Virus entry

PMID:
24878525
PMCID:
PMC4107043
DOI:
10.1016/j.bbrc.2014.05.095
[Indexed for MEDLINE]
Free PMC Article

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