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Eur J Pharmacol. 1996 Sep 26;312(2):183-7.

Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment.

Author information

1
Inst. of Otolaryngol. II, Milano University, Italy. cefisnmo@mbox.vol.it

Abstract

We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed.

PMID:
8894594
DOI:
10.1016/0014-2999(96)00588-2
[Indexed for MEDLINE]

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