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Nat Commun. 2017 Oct 17;8(1):990. doi: 10.1038/s41467-017-01217-9.

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma.

Author information

1
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
2
Gynecologic Oncology, Mercy Medical Center, Baltimore, MD, 21202, USA.
3
Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, 10016, USA.
4
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, 21287, USA.
5
Department of Pathology, University Health Network, Toronto, Canada, M5G 2C4.
6
Departments of Pathology, Gynecology and Obstetrics and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA.
7
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
8
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Douglas.levine@nyumc.org.
9
Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, 10016, USA. Douglas.levine@nyumc.org.

Abstract

Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions. The RNA sequence and the miRNA data did not identify any clear separation between cases with and without STIC lesions. HGSCs had molecular profiles more similar to normal fallopian tube epithelium than ovarian surface epithelium or peritoneum. The data suggest that the molecular features of HGSCs with and without associated STIC lesions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube among all cases.High-grade serous carcinomas (HGSCs) are associated with precursor lesions (STICs) in the fallopian epithelium in only half of the cases. Here the authors report the molecular analysis of HGSCs with and without associated STICs and show similar profiles supporting a common origin for all HGSCs.

PMID:
29042553
PMCID:
PMC5645359
DOI:
10.1038/s41467-017-01217-9
[Indexed for MEDLINE]
Free PMC Article

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