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Head Neck. 2017 Jan;39(1):48-55. doi: 10.1002/hed.24527. Epub 2016 Jun 14.

Improved local and regional control with radiotherapy for Merkel cell carcinoma of the head and neck.

Author information

1
Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
2
Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
3
Departments of Pathology & Cell Biology and Dermatology, University of South Florida Morsani College of Medicine, Tampa, Florida.
4
Department of Head and Neck and Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
5
Departments of Oncologic Sciences and Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida.

Abstract

BACKGROUND:

We hypothesized that radiotherapy (RT) would improve both local and regional control with Merkel cell carcinoma of the head and neck.

METHODS:

A single-institution institutional review board-approved study was performed including 113 patients with nonmetastatic Merkel cell carcinoma of the head and neck. Postoperative RT was delivered to the primary tumor bed (71.7% cases) ± draining lymphatics (33.3% RT cases).

RESULTS:

Postoperative local RT was associated with improved local control (3-year actuarial local control 89.4% vs 68.1%; p = .005; Cox hazard ratio [HR] 0.18; 95% confidence interval [CI] = 0.06-0.55; p = .002). Similarly, regional RT was associated with improved regional control (3-year actuarial regional control 95.0% vs 66.7%; p = .008; Cox HR = 0.09; 95% CI = 0.01-0.69; p = .02). Regional RT played an important role for both clinical node-negative patients (3-year regional control 100% vs 44.7%; p = .03) and clinical/pathological node-positive patients (3-year regional control 90.9% vs 55.6%; p = .047).

CONCLUSION:

Local RT was beneficial for all patients with Merkel cell carcinoma of the head and neck, whereas regional RT was beneficial for clinical node-negative and clinical/pathological node-positive patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 48-55, 2017.

KEYWORDS:

Merkel cell carcinoma; local control; radiotherapy; regional control

PMID:
27300153
DOI:
10.1002/hed.24527
[Indexed for MEDLINE]

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