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Genome Biol. 2016 Apr 14;17:68. doi: 10.1186/s13059-016-0933-0.

Single-cell profiling of lncRNAs in the developing human brain.

Author information

1
Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
2
Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA. howchang@stanford.edu.

Abstract

Single-cell RNA-seq in samples from the human neocortex demonstrate that long noncoding RNAs (lncRNAs) are abundantly expressed in specific individual brain cells, despite being hard to detect in bulk samples. This result suggests that the lncRNAs might have important functions in specific cell types in the brain.

PMID:
27079200
PMCID:
PMC4831122
DOI:
10.1186/s13059-016-0933-0
[Indexed for MEDLINE]
Free PMC Article

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