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Ann Neurol. 2016 Feb;79(2):178-89. doi: 10.1002/ana.24560. Epub 2015 Dec 9.

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk.

Author information

1
Program in Translational Neuropsychiatric Genomics and Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA.
2
Harvard Medical School, Boston, MA.
3
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
4
Division of Neuroimmunology and Neurovirology, National Institute for Neurologic Diseases and Stroke, Bethesda, MD.

Abstract

The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects.

PMID:
26583565
PMCID:
PMC4778957
DOI:
10.1002/ana.24560
[Indexed for MEDLINE]
Free PMC Article

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