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Int J Obes (Lond). 2015 Nov;39(11):1662-5. doi: 10.1038/ijo.2015.144. Epub 2015 Aug 4.

A novel gene THSD7A is associated with obesity.

Author information

1
CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
2
School of Life Sciences, Manipal University, Karnataka, India.
3
Shri Dharmasthala Manjunatheshwara College of Ayurveda, Karnataka, India.
4
Sinhgad College of Engineering, Maharashtra, India.
5
Foundation for Revitalization of Local Health Traditions, Karnataka, India.
6
Department of Statistics, Manipal University, Karnataka, India.
7
Interdisciplinary School of Health Sciences, University of Pune, Maharashtra, India.
8
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Karnataka, India.

Abstract

Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P⩽3.75 × 10(-5)), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10(-5), 8.922 × 10(-6) and 2.504 × 10(-9) in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.

PMID:
26238973
DOI:
10.1038/ijo.2015.144
[Indexed for MEDLINE]

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