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Inflamm Res. 2015 May;64(5):275-86. doi: 10.1007/s00011-015-0812-2. Epub 2015 Mar 19.

Inflammation and prostate cancer: friends or foe?

Author information

1
Department of Urology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

Abstract

INTRODUCTION:

Prostate cancer is the most common non-cutaneous malignancy diagnosed in men. Moving from histological observations since a long time, it has been recognized that innate and adaptive immunity actively participates in the pathogenesis, surveillance, and progression of prostate cancer.

MATERIALS AND METHODS:

A PubMed and Web of Science databases search was performed for studies providing evidence on the roles of the innate and adaptive immunity during the development and progression of prostate cancer.

CONCLUSIONS:

There are growing evidences that chronic inflammation is involved in the regulation of cellular events in prostate carcinogenesis, including disruption of the immune response and regulation of the tumor microenvironment. This review discusses the role played by the innate and adaptive immune system in the local progression of prostate cancer, and the prognostic information that we can currently understand and exploit.

PMID:
25788425
DOI:
10.1007/s00011-015-0812-2
[Indexed for MEDLINE]

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