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J Nutr Metab. 2014;2014:985373. doi: 10.1155/2014/985373. Epub 2014 Sep 11.

Effect of a Mediterranean Diet Intervention on Dietary Glycemic Load and Dietary Glycemic Index: The PREDIMED Study.

Author information

1
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Luis Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain ; Department of Nutrition and Food Science, School of Pharmacy, University of Granada, Campus Universitario de la Cartuja, 18071 Granada, Spain.
2
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Luis Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain ; Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain.
3
Department of Nutrition and Food Science, School of Pharmacy, University of Granada, Campus Universitario de la Cartuja, 18071 Granada, Spain.
4
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Irunlarrea 1, Pamplona, 31080 Navarra, Spain.
5
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain.
6
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Human Nutrition Department, School of Medicine, University Rovira i Virgili, Sant Llorenc 21, Reus, 43201 Tarragona, Spain.
7
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Cardiovascular Risk and Nutrition Research Group, Institut Municipal d'Investigació Medica (IMIM), Institut de Recerca del Hospital del Mar, Dr. Aiguader 88, 08003 Barcelona, Spain.
8
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Preventive Medicine, School of Medicine, University of Valencia, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain.
9
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Preventive Medicine, School of Medicine, University of Malaga, Campus de Teatinos s/n, 29071 Malaga, Spain.
10
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Damasco s/n, 41007 Sevilla, Spain.
11
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Internal Medicine Service, Hospital of Bellvitge, c/Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
12
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Cardiology, Hospital Txagorritxu, Jose Achotegui s/n, Vitoria, 01009 Alava, Spain.
13
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Institute of Health Sciences (IUNICS), University of Balearic Islands and Hospital Son Espases, Carretera de Valldemossa 79, 07120 Palma de Mallorca, Spain ; Department of Cardiology, Hospital Universitario Son Dureta, Andrea Doria 55, 07014 Palma de Mallorca, Spain.
14
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of Nutrition and Bromatology, School of Pharmacy, University of Barcelona, Avenida Joan XXIII s/n, 08028 Barcelona, Spain.
15
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Group of Nutrition and Lipid Metabolism, Instituto de la Grasa (CSIC), Avenida Padre García Tejero 4, 41012 Seville, Spain.
16
Cardiovascular Risk and Nutrition Research Group, Institut Municipal d'Investigació Medica (IMIM), Institut de Recerca del Hospital del Mar, Dr. Aiguader 88, 08003 Barcelona, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Melchor Fernández Almagro 3-5, 28029 Madrid, Spain.
17
Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN, CB06/03), Instituto de Salud Carlos III, Edificio D 1 º Planta, Hospital Clínico Universitario de Santiago de Compostela Choupana s/n, 15706 Santiago de Compostela, Spain ; Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clinic, IDIBAPS, Villarroel 170, 08036 Barcelona, Spain.

Abstract

OBJECTIVE:

To compare the one year effect of two dietary interventions with MeDiet on GL and GI in the PREDIMED trial.

METHODS:

Participants were older subjects at high risk for cardiovascular disease. This analysis included 2866 nondiabetic subjects. Diet was assessed with a validated 137-item food frequency questionnaire (FFQ). The GI of each FFQ item was assigned by a 5-step methodology using the International Tables of GI and GL Values. Generalized linear models were fitted to assess the relationship between the intervention group and dietary GL and GI at one year of follow-up, using control group as reference.

RESULTS:

Multivariate-adjusted models showed an inverse association between GL and MeDiet + extra virgin olive oil (EVOO) group: β = -8.52 (95% CI: -10.83 to -6.20) and MeDiet + Nuts group: β = -10.34 (95% CI: -12.69 to -8.00), when comparing with control group. Regarding GI, β = -0.93 (95% CI: -1.38 to -0.49) for MeDiet + EVOO, β = -1.06 (95% CI: -1.51 to -0.62) for MeDiet + Nuts when comparing with control group.

CONCLUSION:

Dietary intervention with MeDiet supplemented with EVOO or nuts lowers dietary GL and GI.

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