Format

Send to

Choose Destination

See 1 citation:

PLoS One. 2014 Sep 30;9(9):e105881. doi: 10.1371/journal.pone.0105881. eCollection 2014.

Oxidative stress is associated with an increased antioxidant defense in elderly subjects: a multilevel approach.

Author information

1
Unitat de Suport a la Recerca Tarragona-Reus, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Tarragona, Spain; CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain.
2
Epidemiology and Cardiovascular Genetics Research Group, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
3
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain.
4
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Human Nutrition Unit, School of Medicine, University Rovira i Virgili, Reus, Spain.
5
Department of Preventive Medicine and Public Health, University of Navarra-Osasunbidea, Servicio Navarro de Salud, Pamplona, Spain.
6
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Department of Internal Medicine, Hospital Clinic, Institut dInvestigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
7
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain.
8
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain.
9
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Institute for Health Sciences Investigation, IdISPa, Palma de Mallorca, Spain.
10
Department of Cardiology, Hospital Txangorritxu, Vitoria, Spain.
11
Department of Epidemiology, School of Medicine of Malaga, Malaga, Spain.
12
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain.
13
Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Sevilla, Spain.
14
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Instituto de la Grasa, CSIC, Sevilla, Spain.
15
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Service of Clinical Analysis, Doctor Peset University Hospital, University of Valencia, Valencia, Spain.
16
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Madrid, Spain; Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain.

Abstract

BACKGROUND:

Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients.

METHODS:

We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures.

RESULTS:

Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance =  013.5; P<0.001). Between-participants variability within a PHCC accounted for 89% of the total variation. Both glucose and oxidized LDL were positively associated with GSH-Px activity after adjustment for possible confounder variables (P = 0.03 and P = 0.01, respectively).

CONCLUSION:

In a population at high cardiovascular risk, a positive linear association was observed between plasma GSH-Px activity and both glucose and ox-LDL levels. The high GSH-Px activity observed when an oxidative stress situation occurred, such as hyperglycemia and lipid oxidative damage, could be interpreted as a healthy defensive response against oxidative injury in our cardiovascular risk population.

PMID:
25269026
PMCID:
PMC4182040
DOI:
10.1371/journal.pone.0105881
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center