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WormBook. 2013 Jul 10:1-34. doi: 10.1895/wormbook.1.22.2.

TGF-β signaling in C. elegans.

Author information

1
Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, TX 77843, USA.

Abstract

Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell identity, function, and survival in multicellular animals. Genes encoding five TGF-β family members are present in the genome of C. elegans. Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway. No function has yet been associated with the remaining two ligands. Here we summarize these signaling pathways and their biological functions.

PMID:
23908056
PMCID:
PMC5081272
DOI:
10.1895/wormbook.1.22.2
[Indexed for MEDLINE]
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