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Sci Rep. 2018 Apr 26;8(1):6587. doi: 10.1038/s41598-018-24962-3.

Survey and evaluation of mutations in the human KLF1 transcription unit.

Author information

1
Department of Cell, Developmental, and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, 10029, USA.
2
Department of Medicine, Northwestern University, Chicago, IL, 60611, USA.
3
Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA.
4
Cellular Therapy Laboratory, New York Blood Center, New York, NY, 10065, USA.
5
Department of Medicine, Mount Sinai School of Medicine, New York, NY, 10029, USA.
6
Department of Cell, Developmental, and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, 10029, USA. james.bieker@mssm.edu.
7
Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, 10029, USA. james.bieker@mssm.edu.
8
Black Familly Stem Cell Institute, Mount Sinai School of Medicine, New York, NY, 10029, USA. james.bieker@mssm.edu.
9
Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY, 10029, USA. james.bieker@mssm.edu.

Abstract

Erythroid Krüppel-like Factor (EKLF/KLF1) is an erythroid-enriched transcription factor that plays a global role in all aspects of erythropoiesis, including cell cycle control and differentiation. We queried whether its mutation might play a role in red cell malignancies by genomic sequencing of the KLF1 transcription unit in cell lines, erythroid neoplasms, dysplastic disorders, and leukemia. In addition, we queried published databases from a number of varied sources. In all cases we only found changes in commonly notated SNPs. Our results suggest that if there are mutations in KLF1 associated with erythroid malignancies, they are exceedingly rare.

PMID:
29700354
PMCID:
PMC5920080
DOI:
10.1038/s41598-018-24962-3
[Indexed for MEDLINE]
Free PMC Article

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