Format

Send to

Choose Destination
Sci Rep. 2017 Aug 31;7(1):10185. doi: 10.1038/s41598-017-10547-z.

The global view of mRNA-related ceRNA cross-talks across cardiovascular diseases.

Author information

1
Department of Pharmacology, Harbin Medical University-Daqing, Daqing, 163319, China.
2
Department of Medical Informatics, Harbin Medical University-Daqing, Daqing, 163319, China.
3
Department of Medical Informatics, Harbin Medical University-Daqing, Daqing, 163319, China. lcqbio@163.com.
4
Department of Pharmacology, Harbin Medical University-Daqing, Daqing, 163319, China. shlhmu@163.com.

Abstract

Competing endogenous RNA (ceRNA) have received wide attention because they are a novel way to regulate genes through sharing microRNAs (miRNAs) that are crucial for complex processes in many diseases. However, no systematic analysis of ceRNA mechanism in cardiovascular disease (CVD) is known. To gain insights into the global properties of ceRNAs in multi-CVDs, we constructed the global view of mRNA-related ceRNA cross-talk in eight major CVDs from ~2,800 samples. We found common features that could be used to uncover similarities among different CVDs and highlighted a common core ceRNA network across CVDs. Comparative analysis of hub ceRNAs in each network revealed three types of hubs, which might play key roles in diverse biological processes. Importantly, by combining CVD-related pathway genes with ceRNA-ceRNA interactions, common modules that might exert functions in specific mechanisms were identified. In addition, our study investigated a potential mechanistic linkage between pathway cross-talk and ceRNA cross-talk. In summary, this study uncovered and systematically characterized global properties of mRNA-related ceRNA cross-talks across CVDs, which may provide a new layer for exploring biological mechanisms and shed new light on cardiology.

PMID:
28860540
PMCID:
PMC5579186
DOI:
10.1038/s41598-017-10547-z
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center