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Cell Metab. 2014 Apr 1;19(4):549-50. doi: 10.1016/j.cmet.2014.03.022.

Metabolism goes viral.

Author information

1
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA.
2
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. Electronic address: oshea@salk.edu.

Abstract

Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.

PMID:
24703688
PMCID:
PMC4097405
DOI:
10.1016/j.cmet.2014.03.022
[Indexed for MEDLINE]
Free PMC Article

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