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Fertil Steril. 2014 Jun;101(6):1773-80.e1. doi: 10.1016/j.fertnstert.2014.02.047. Epub 2014 Mar 28.

Differences in ovarian hormones in relation to parity and time since last birth.

Author information

1
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, New York. Electronic address: emily_barrett@urmc.rochester.edu.
2
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
3
Division of Environmental and Occupational Disease Control, California Department of Public Health, Richmond, California.
4
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Abstract

OBJECTIVE:

To examine ovarian function in relation to parity and time since last birth.

DESIGN:

Cross-sectional study.

SETTING:

Health-care program in California.

PATIENT(S):

346 naturally cycling women, aged 18 to 39 years.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Mean follicular urinary estradiol metabolite concentration (E1C) (cycle days -8 to -1), mean luteal progesterone metabolite concentration (PdG) (days 0 to +10), and cycle phase lengths in ovulatory cycles.

RESULT(S):

After the women had collected daily urine samples for up to eight menstrual cycles, we measured the E1C and PdG using enzyme-linked immunoassay. The cycle phase lengths were calculated from the hormone profiles and daily diaries. Women who had given birth within the previous 3 years had lower E1C than the nulliparous women and women who last given birth >3 years earlier. Among the parous women, E1C was positively associated with the time since last birth. Women who last gave birth >3 years earlier had longer follicular phases than the nulliparous women. There were no associations between parity and PdG or luteal phase length.

CONCLUSION(S):

Our cross-sectional data suggest that ovarian function differs in nulliparous and parous women and is positively associated with the time since last birth. Longitudinal research is needed to explore within-woman changes in ovarian function prepartum and postpartum.

KEYWORDS:

Estradiol; fecundity; menstrual cycle; motherhood; ovarian function

PMID:
24684956
PMCID:
PMC4041832
DOI:
10.1016/j.fertnstert.2014.02.047
[Indexed for MEDLINE]
Free PMC Article

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