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Items: 1 to 20 of 327


New insights into long noncoding RNAs and pseudogenes in prognosis of renal cell carcinoma.

Chen B, Wang C, Zhang J, Zhou Y, Hu W, Guo T.

Cancer Cell Int. 2018 Oct 11;18:157. doi: 10.1186/s12935-018-0652-6. eCollection 2018.


Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant.

Cohen SB, Bainter W, Johnson JL, Lin TY, Wong JCY, Wallace J, Jones J, Mir F, Qamar F, Cantley LC, Geha RS, Chou J.

J Allergy Clin Immunol. 2018 Oct 15. pii: S0091-6749(18)31440-4. doi: 10.1016/j.jaci.2018.10.005. [Epub ahead of print]


Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) Defects.

Jhamnani RD, Nunes-Santos CJ, Bergerson J, Rosenzweig SD.

Front Immunol. 2018 Sep 26;9:2172. doi: 10.3389/fimmu.2018.02172. eCollection 2018. Review.


Genome-wide scan reveals divergent selection among taurine and zebu cattle populations from different regions.

Edea Z, Dadi H, Dessie T, Uzzaman MR, Rothschild MF, Kim ES, Sonstegard TS, Kim KS.

Anim Genet. 2018 Dec;49(6):550-563. doi: 10.1111/age.12724. Epub 2018 Sep 23.


The Treatment of Activated PI3Kδ Syndrome.

Coulter TI, Cant AJ.

Front Immunol. 2018 Sep 7;9:2043. doi: 10.3389/fimmu.2018.02043. eCollection 2018. Review.


Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses.

Wray-Dutra MN, Al Qureshah F, Metzler G, Oukka M, James RG, Rawlings DJ.

J Exp Med. 2018 Oct 1;215(10):2485-2496. doi: 10.1084/jem.20180617. Epub 2018 Sep 7.


Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease.

Burke JE.

Mol Cell. 2018 Sep 6;71(5):653-673. doi: 10.1016/j.molcel.2018.08.005. Review.


CDR1as is overexpressed in laryngeal squamous cell carcinoma to promote the tumour's progression via miR-7 signals.

Zhang J, Hu H, Zhao Y, Zhao Y.

Cell Prolif. 2018 Dec;51(6):e12521. doi: 10.1111/cpr.12521. Epub 2018 Sep 4.


MALAT1-miR663a negative feedback loop in colon cancer cell functions through direct miRNA-lncRNA binding.

Tian W, Du Y, Ma Y, Gu L, Zhou J, Deng D.

Cell Death Dis. 2018 Aug 28;9(9):857. doi: 10.1038/s41419-018-0925-y.


Identification of a novel de novo gain-of-function mutation of PIK3CD in a patient with activated phosphoinositide 3-kinase δ syndrome.

Luo Y, Xia Y, Wang W, Li Z, Jin Y, Gong Y, He T, Li Q, Li C, Yang J.

Clin Immunol. 2018 Aug 20;197:60-67. doi: 10.1016/j.clim.2018.08.007. [Epub ahead of print]


NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2 +ve breast cancer signaling pathways.

Ramos J, Das J, Felty Q, Yoo C, Poppiti R, Murrell D, Foster PJ, Roy D.

Breast Cancer Res Treat. 2018 Nov;172(2):469-485. doi: 10.1007/s10549-018-4905-9. Epub 2018 Aug 20.


Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.

Cannons JL, Preite S, Kapnick SM, Uzel G, Schwartzberg PL.

Front Immunol. 2018 Aug 2;9:1758. doi: 10.3389/fimmu.2018.01758. eCollection 2018.


Associations of high-altitude polycythemia with polymorphisms in PIK3CD and COL4A3 in Tibetan populations.

Fan X, Ma L, Zhang Z, Li Y, Hao M, Zhao Z, Zhao Y, Liu F, Liu L, Luo X, Cai P, Li Y, Kang L.

Hum Genomics. 2018 Jul 27;12(1):37. doi: 10.1186/s40246-018-0169-z.


Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor.

Liang X, Li F, Chen C, Jiang Z, Wang A, Liu X, Ge J, Hu Z, Yu K, Wang W, Zou F, Liu Q, Wang B, Wang L, Zhang S, Wang Y, Liu Q, Liu J.

Eur J Med Chem. 2018 Aug 5;156:831-846. doi: 10.1016/j.ejmech.2018.07.036. Epub 2018 Jul 17.


Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer.

Zhang X, Yang D, Wei Y.

Onco Targets Ther. 2018 Jul 10;11:3979-3987. doi: 10.2147/OTT.S158316. eCollection 2018.


Germline-activating mutations in PIK3CD compromise B cell development and function.

Avery DT, Kane A, Nguyen T, Lau A, Nguyen A, Lenthall H, Payne K, Shi W, Brigden H, French E, Bier J, Hermes JR, Zahra D, Sewell WA, Butt D, Elliott M, Boztug K, Meyts I, Choo S, Hsu P, Wong M, Berglund LJ, Gray P, O'Sullivan M, Cole T, Holland SM, Ma CS, Burkhart C, Corcoran LM, Phan TG, Brink R, Uzel G, Deenick EK, Tangye SG.

J Exp Med. 2018 Aug 6;215(8):2073-2095. doi: 10.1084/jem.20180010. Epub 2018 Jul 17.


PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.

Blesinger H, Kaulfuß S, Aung T, Schwoch S, Prantl L, Rößler J, Wilting J, Becker J.

PLoS One. 2018 Jul 9;13(7):e0200343. doi: 10.1371/journal.pone.0200343. eCollection 2018.


Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma.

Sang L, Wang XM, Xu DY, Zhao WJ.

World J Gastroenterol. 2018 Jun 28;24(24):2605-2616. doi: 10.3748/wjg.v24.i24.2605.


Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma.

Li F, Wang Q, Xiong X, Wang C, Liu X, Liao Z, Li K, Xie B, Lin Y.

Cancer Manag Res. 2018 Jun 15;10:1553-1563. doi: 10.2147/CMAR.S158547. eCollection 2018.


Deciphering signature of selection affecting beef quality traits in Angus cattle.

Taye M, Yoon J, Dessie T, Cho S, Oh SJ, Lee HK, Kim H.

Genes Genomics. 2018 Jan;40(1):63-75. doi: 10.1007/s13258-017-0610-z. Epub 2017 Sep 30.


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