Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1993 1
1995 2
1996 2
1997 2
1998 1
2000 1
2003 1
2004 1
2005 2
2007 4
2008 5
2009 5
2010 7
2011 5
2012 7
2013 10
2014 6
2015 10
2016 6
2017 10
2018 7
2019 10
2020 7
2021 6
2022 13
2023 5
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

126 results

Results by year

Filters applied: . Clear all
Page 1
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Remes SM, Leijon H, Vesterinen T, Louhimo J, Pulkkinen V, Ezer S, Kere J, Haglund C, Arola J. Remes SM, et al. APMIS. 2020 Nov;128(11):563-572. doi: 10.1111/apm.13071. Epub 2020 Sep 28. APMIS. 2020. PMID: 32794589 Free PMC article.
PCSK2 expression did not correlate with Ki-67 in well-differentiated NETs. Our data suggest that PCSK2 positivity can indicate the location of the primary tumor. ...
PCSK2 expression did not correlate with Ki-67 in well-differentiated NETs. Our data suggest that PCSK2 positivity can indicate …
Susceptibility of PCSK2 Polymorphism to Hirschsprung Disease in Southern Chinese Children.
Wang B, Fang W, Qin D, He Q, Lan C. Wang B, et al. Clin Exp Gastroenterol. 2023 May 15;16:59-64. doi: 10.2147/CEG.S393340. eCollection 2023. Clin Exp Gastroenterol. 2023. PMID: 37215434 Free PMC article.
It has been reported that single nucleotide polymorphisms (SNPs) of proprotein convertase subtilisin/kexin type 2 (PCSK2) gene are associated with HSCR. However, the correlation of HSCR in southern Chinese population is still unclear. ...CONCLUSION: In summary, we report t …
It has been reported that single nucleotide polymorphisms (SNPs) of proprotein convertase subtilisin/kexin type 2 (PCSK2) gene are as …
Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2.
Zanesco AM, Mendes NF, Engel DF, Gaspar RS, Sidarta-Oliveira D, Donato J Jr, Velloso LA. Zanesco AM, et al. Cells. 2022 Jun 22;11(13):1996. doi: 10.3390/cells11131996. Cells. 2022. PMID: 35805082 Free PMC article.
This was accompanied by reduced expression of the Pomc endopeptidases, protein convertase 2, which are encoded by Pcsk2, and by the loss of the high-fat-diet-induced effect to inhibit the production of alpha-MSH. ...
This was accompanied by reduced expression of the Pomc endopeptidases, protein convertase 2, which are encoded by Pcsk2, and by the l …
Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.
Winters A, Ramos-Molina B, Jarvela TS, Yerges-Armstrong L, Pollin TI, Lindberg I. Winters A, et al. Diabetes Res Clin Pract. 2017 Sep;131:82-90. doi: 10.1016/j.diabres.2017.06.023. Epub 2017 Jul 3. Diabetes Res Clin Pract. 2017. PMID: 28719828 Free PMC article.
AIMS: In humans, noncoding variants of PCSK2, the gene encoding prohormone convertase 2 (PC2), have been previously associated with risk for and age of onset of type 2 diabetes (T2D). ...METHODS: Exome-wide genotyping was performed on 1725 Old Order Amish (OOA) subjects. …
AIMS: In humans, noncoding variants of PCSK2, the gene encoding prohormone convertase 2 (PC2), have been previously associated with r …
Serum Exosomal Long Noncoding RNA pcsk2-2:1 As A Potential Novel Diagnostic Biomarker For Gastric Cancer.
Cai C, Zhang H, Zhu Y, Zheng P, Xu Y, Sun J, Zhang M, Lan T, Gu B, Li S, Ma P. Cai C, et al. Onco Targets Ther. 2019 Nov 25;12:10035-10041. doi: 10.2147/OTT.S229033. eCollection 2019. Onco Targets Ther. 2019. PMID: 31819499 Free PMC article.
Moreover, the expression level of Exo-Lnc RNA PCSK2-2:1 was correlated with tumor size (p=0.0441), tumor stage (p=0.0061), and venous invasion (p=0.0367). The area under the curve of Exo-Lnc RNA PCSK2-2:1 was 0.896. At the optimal cut-off value, the diagnostic sensi …
Moreover, the expression level of Exo-Lnc RNA PCSK2-2:1 was correlated with tumor size (p=0.0441), tumor stage (p=0.0061), and venous …
PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.
Gagnon J, Mayne J, Chen A, Raymond A, Woulfe J, Mbikay M, Chrétien M. Gagnon J, et al. Life Sci. 2011 Jan 31;88(5-6):212-7. doi: 10.1016/j.lfs.2010.11.010. Epub 2010 Nov 16. Life Sci. 2011. PMID: 21092739
AIMS: To examine the effects of global lack of proprotein convertase subtilisin/kexin 2 (PCSK2) in mouse on intestinal motility, post-fast refeeding response and levels of several PCSK-generated peptides known to regulate food intake and processing. ...SIGNIFICANCE: The al …
AIMS: To examine the effects of global lack of proprotein convertase subtilisin/kexin 2 (PCSK2) in mouse on intestinal motility, post …
Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population.
Chang TJ, Chiu YF, Sheu WH, Shih KC, Hwu CM, Quertermous T, Jou YS, Kuo SS, Chang YC, Chuang LM. Chang TJ, et al. Sci Rep. 2015 Nov 26;5:14380. doi: 10.1038/srep14380. Sci Rep. 2015. PMID: 26607656 Free PMC article.
Proprotein convertase subtilisin/kexin type 2 (PCSK2) is a prohormone processing enzyme involved in insulin and glucagon biosynthesis. We previously found the genetic polymorphism of PCSK2 on chromosome 20 was responsible for the linkage peak of several glucose home …
Proprotein convertase subtilisin/kexin type 2 (PCSK2) is a prohormone processing enzyme involved in insulin and glucagon biosynthesis …
Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
Jonsson A, Isomaa B, Tuomi T, Eriksson JG, Groop L, Lyssenko V. Jonsson A, et al. Diabetologia. 2012 Dec;55(12):3245-51. doi: 10.1007/s00125-012-2728-5. Epub 2012 Sep 26. Diabetologia. 2012. PMID: 23011353
METHODS: Replication of PCSK2 variants against insulin secretion included 7,682 non-diabetic Scandinavian individuals. ...The presence of the PCSK2 rs2208203 risk allele did not influence gene expression, nor did it show an apparent risk in terms of type 2 diabetes. …
METHODS: Replication of PCSK2 variants against insulin secretion included 7,682 non-diabetic Scandinavian individuals. ...The presenc …
Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2.
Morash MG, MacDonald AB, Croll RP, Anini Y. Morash MG, et al. Gen Comp Endocrinol. 2009 Jun;162(2):179-87. doi: 10.1016/j.ygcen.2009.03.013. Epub 2009 Mar 28. Gen Comp Endocrinol. 2009. PMID: 19332069
In this work, we cloned and sequenced the cDNA of pcsk1 and pcsk2 from zebrafish (Danio rerio). pcsk1 is a 2268bp ORF, whose 755 amino acid protein product is identical to that predicted from the genome sequence. pcsk2 is a 1941bp ORF, encoding a 646 amino acid pept …
In this work, we cloned and sequenced the cDNA of pcsk1 and pcsk2 from zebrafish (Danio rerio). pcsk1 is a 2268bp ORF, whose 755 amin …
Replication Activities of Major 5' Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells.
Callon D, Guedra A, Lebreil AL, Heng L, Bouland N, Fornès P, Berri F, Andreoletti L. Callon D, et al. Viruses. 2022 Dec 13;14(12):2781. doi: 10.3390/v14122781. Viruses. 2022. PMID: 36560784 Free PMC article.
Moreover, in infected mouse pancreases, we showed a decrease in pro-hormone convertase 2 (PCSK2) mRNA, associated with a decrease in insulin plasmatic concentration. Finally, transfection of synthetic CVB-TD50 RNA forms into cultured rodent pancreatic beta cells demonstrat …
Moreover, in infected mouse pancreases, we showed a decrease in pro-hormone convertase 2 (PCSK2) mRNA, associated with a decrease in …
126 results