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Semin Cell Dev Biol. 2018 Sep;81:110-120. doi: 10.1016/j.semcdb.2017.08.043. Epub 2017 Aug 26.

Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.

Author information

1
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: peter.espenshade@jhmi.edu.

Abstract

Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a highly oxygen-dependent process. In this review, we focus on recent advances in our understanding of the transcriptional regulation and coordination of the low oxygen response across fungal species, paying particular attention to pathogenic fungi. Comparison of lipid homeostasis pathways in these organisms suggests common mechanisms of transcriptional regulation and points toward untapped potential to target low oxygen adaptation in antifungal development.

KEYWORDS:

Anti-fungal drug; Fungi; Hypoxia; Lipid metabolism; Transcription

PMID:
28851600
PMCID:
PMC5826825
[Available on 2019-09-01]
DOI:
10.1016/j.semcdb.2017.08.043

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