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J Burn Care Res. 2016 Jul-Aug;37(4):e374-9. doi: 10.1097/BCR.0000000000000233.

Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation.

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1
From the *Department of Surgery, San Antonio Military Medical Center, Fort Sam Houston, Texas; †U.S. Army Institute of Surgical Research, JBSA, ‡Department of Pathology, San Antonio Military Medical Center, Fort Sam Houston, Texas; and §Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Abstract

Fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients. To the best of our knowledge, the authors present the first case series in burn patients in whom calcium oxalate nephropathy has been identified after high-dose vitamin C therapy.

PMID:
25812044
PMCID:
PMC4933579
DOI:
10.1097/BCR.0000000000000233
[Indexed for MEDLINE]
Free PMC Article

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